850221-69-1

Basic information

• Product Name: Methanone, (6-chloropyrazinyl)(4-methoxyphenyl)-
• CAS NO: 850221-69-1
• Molecular Formula: C12H9ClN2O2
• Molecular Weight: 248.669
• Mol File: 850221-69-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methanone, (6-chloropyrazinyl)(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (6-chloropyrazinyl)(4-methoxyphenyl)-(850221-69-1)
• EPA Substance Registry System: Methanone, (6-chloropyrazinyl)(4-methoxyphenyl)-(850221-69-1)

Safety Data

• Hazardous Substances Data: 850221-69-1(Hazardous Substances Data)

Upstream product

• 850221-68-0 2-chloro-6-(tri-n-butylstannyl)pyrazine 
• 100-07-2 4-methoxy-benzoyl chloride 

Downstream Products

• 700875-15-6 2-(1-oxo-[4-methoxyphenyl]methyl)-6-(4-methoxyphenyl)pyrazine 
• 1149759-62-5 2-((4-methoxyphenyl)carbonyl)-6-phenylpyrazine 
• 1149759-61-4 6-(4-aminophenyl)-2-((4-methoxyphenyl)carbonyl)pyrazine 
• 1149759-63-6 6-(4-mercaptophenyl)-2-((4-methoxyphenyl)carbonyl)pyrazine 
• 1149759-64-7 6-(4-hydroxyphenyl)-2-((4-methoxyphenyl)carbonyl)pyrazine 
• 1149759-68-1 6-(3,4-dimethoxyphenyl)-2-((4-methoxyphenyl)carbonyl)pyrazine 
• 1149759-67-0 6-(3-hydroxyphenyl)-2-((4-methoxyphenyl)carbonyl)pyrazine 
• 1149759-66-9 6-(4-biphenylyl)-2-((4-methoxyphenyl)carbonyl)pyrazine 
• 1149759-65-8 6-(4-fluorophenyl)-2-((4-methoxyphenyl)carbonyl)pyrazine 
• 252026-25-8 2-(4-hydroxyphenyl)carbonyl-6-(4-hydroxyphenyl)pyrazine 
• 850221-85-1 2-(1-oxo-[4-methoxyphenyl]methyl)-3-(4-methoxyphenyl)-5-(2-[4-methoxyphenyl]-1,3-dioxolan-2-yl)pyrazine 
• 850221-86-2 2,5-di-(1-oxo-[4-methoxyphenyl]methyl)-3-(4-methoxyphenyl)pyrazine 
• 850221-83-9 3-chloro-2-(1-hydroxy-[4-methoxyphenyl]methyl)-5-(2-[4-methoxyphenyl]-1,3-dioxolan-2-yl)pyrazine 
• 850221-84-0 3-chloro-2-(1-oxo-[4-methoxyphenyl]methyl)-5-(2-[4-methoxyphenyl]-1,3-dioxolan-2-yl)pyrazine 

Relevant articles and documents

Palladium-catalyzed cross-coupling of aroyl chlorides with aryl stannanes in the presence of triethylsilane: Efficient access to aromatic ketones

Herein, we report the development of a palladium-catalyzed cross-coupling reaction that focuses on the preparation of aromatic ketones. Aroyl chlorides react quickly at 120 °C with aryl stannanes in the presence of Pd(PPh3)4 and Et3SiH to efficiently give the corresponding ketones without the formation of significant decarbonylated byproducts. In other words, the decarbonylative side reaction is practically suppressed by simply adding Et3SiH to the reaction mixture, which reduces the amount of biaryl impurities in the products.

Synthesis of pyrazine alcaloids from Botryllus leachi. diazines 43

(Chemical Equation Presented) Regioselective metalation of pyrazines and cross-coupling reactions provides an easy access to botryllazines A and B and to an isomer of botryllazine A with good yields from chloropyrazine.