850352-48-6

Basic information

• Product Name: 1-Pentanone, 2-bromo-1-(4-methylphenyl)-
• CAS NO: 850352-48-6
• Molecular Formula: C12H15BrO
• Molecular Weight: 255.155
• Mol File: 850352-48-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Pentanone, 2-bromo-1-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pentanone, 2-bromo-1-(4-methylphenyl)-(850352-48-6)
• EPA Substance Registry System: 1-Pentanone, 2-bromo-1-(4-methylphenyl)-(850352-48-6)

Safety Data

• Hazardous Substances Data: 850352-48-6(Hazardous Substances Data)

Upstream product

• 7642-17-3 1-Methyl-4-((E)-pent-1-enyl)-benzene 
• 108-88-3 toluene 
• 638-29-9 n-valeryl chloride 
• 1671-77-8 n-butyl p-tolyl ketone 

Downstream Products

• 3563-49-3 Pyrovalerone 

Relevant articles and documents

1,3-Dibromo-5,5-dimethylhydantoin (DBH) mediated one-pot syntheses of α-bromo/amino ketones from alkenes in water

α-Bromo ketones are versatile intermediates of high practical utility. Traditional approaches to these compounds are restricted to a relatively hazardous/complex reagent combination, a long reaction time, the use of non-environmentally friendly solvents, or a limited substrate scope. Herein, we describe the development of a new methodology for the preparation of α-bromo ketones from alkenes using 1,3-dibromo-5,5-dimethylhydantoin (DBH) as a bromine source and an oxidant simultaneously. This easy to carry out two-step one-pot protocol proceeds in water and provides high yield of a great variety of α-bromo ketones. Addition of an amine to the intermediate α-bromo ketone further enables the preparation of α-amino ketones in a one-pot sequence.

PYROVALERONE ANALOGS AND THERAPEUTIC USES THEREOF

New compounds that bind to monoamine transporters are described. The compounds of the present invention can be racemic or pure R-or S-enantiomers. Certain preferred compounds of the present invention have a high selectively dopamine transporter versus the serotonin transporter. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.