850568-72-8

Basic information

• Product Name: 4-(TERT-BUTOXYCARBONYL)PHENYLBORONIC ACID
• Synonyms: 4-(TERT-BUTOXYCARBONYL)BENZENEBORONIC ACID;4-(TERT-BUTOXYCARBONYL)BENZENEBORONIC ACID, PINACOL ESTER;4-(TERT-BUTOXYCARBONYL)PHENYLBORONIC ACID;4-TERT-BUTOXYCARBONYLPHENYLBORONIC ACID PINACOL ESTER;4-(T-BUTOXYCARBONYL)PHENYLBORONIC ACID;T-BUTYL 4-BORONOBENZOATE;4-(tert-Butoxycarbonyl)benzeneboronic acid, pinacol ester 97%;tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate
• CAS NO: 850568-72-8
• Molecular Formula: C17H25BO4
• Molecular Weight: 304.19
• Product Categories: blocks;BoronicAcids;Carboxes;Boronic acids;Aryl;Boronic ester;Organoborons
• Mol File: 850568-72-8.mol
• Article Data: 19

Chemical Properties

• Melting Point: 128-132
• Boiling Point: 389.1 °C at 760 mmHg
• Flash Point: 189.1 °C
• Appearance: /
• Density: 1.04 g/cm³
• Vapor Pressure: 6.04E-06mmHg at 25°C
• Refractive Index: 1.517
• Storage Temp.: Keep cold
• CAS DataBase Reference: 4-(TERT-BUTOXYCARBONYL)PHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TERT-BUTOXYCARBONYL)PHENYLBORONIC ACID(850568-72-8)
• EPA Substance Registry System: 4-(TERT-BUTOXYCARBONYL)PHENYLBORONIC ACID(850568-72-8)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• Hazardous Substances Data: 850568-72-8(Hazardous Substances Data)

Usage

General Description

4-(tert-butoxycarbonyl)phenylboronic acid is a chemical compound that is commonly used in organic synthesis and pharmaceutical research. It is a boronic acid derivative with a tert-butoxycarbonyl (Boc) protecting group, which makes it a valuable building block for the synthesis of various organic molecules. 4-(TERT-BUTOXYCARBONYL)PHENYLBORONIC ACID is often used in the Suzuki-Miyaura coupling reaction to form carbon-carbon bonds, and it has also been utilized in the preparation of potential drug candidates for various diseases. Its unique structure and reactivity make it a versatile and important reagent in the field of organic chemistry.

InChI:InChI=1/C11H15BO4/c1-11(2,3)16-10(13)8-4-6-9(7-5-8)12(14)15/h4-7,14-15H,1-3H3

Upstream product

• 180516-87-4 4-carboxyphenylboronic acid pinacol ester 
• 75-65-0 tert-butyl alcohol 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 120363-13-5 tert-butyl 4-iodobenzoate 
• 73183-34-3 bis(pinacol)diborane 
• 586-76-5 4-Bromobenzoic acid 
• 59247-47-1 tert-butyl-4-bromobenzoate 
• 185990-03-8 dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane 
• 865-47-4 potassium tert-butylate 
• 171364-80-0 methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 78782-17-9 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane 
• 712-95-8 tert-butyl 4-chlorobenzoate 

Relevant articles and documents

3D-printed cartridge system for in-flow photo-oxygenation of 7-aminothienopyridinones

A 3D-printed polypropylene (PP) continuous-photoflow cell based on a modular cartridge system was developed for the photo-oxygenation of 7-aminothieno[3,2-c]pyridin-4(5H)-ones, using ambient air as the sole co-reactant. This strategy takes advantage of the versatility of 3D-printing to construct cost-effective meso-scale reactors. In addition to scalability, a short residence time (tR 2 min) in 100-W blue LED light that minimizes the formation of dark, insoluble decomposition products is a tangible benefit of this technology.

Competing dehalogenation versus borylation of aryl iodides and bromides under transition-metal-free basic conditions

In this work, selectivity-controllable base-promoted transition-metal-free borylation and dehalogenation of aryl halides are described. Under the conditions of borylation, the dehalogenation which emerges as a competitive side reaction has been well-controlled by carefully controlling the borylation conditions. On the other hand, the dehalogenation using benzaldehyde as a hydrogen source has also been accomplished. The applications of direct radical borylation and dehalogenation of aryl halides demonstrate their synthetic practicability in pharmaceutical-oriented organic synthesis. Based on the experimental evidences, the tBuOK/1,10-Phen-triggered radical nature of both competitive reactions has been revealed.

METHODS OF MANUFACTURING OF BORON COMPOUND WITHOUT TRANSITION METALS

The present invention refers to aryl boron compound number bath method relates to search, more particularly transition metal catalyst to a tank without the use of boron compounds number is given to the aryl organic halo [ceyn [ceyn] freight method are disclosed to boron. (by machine translation)