85103-40-8

Basic information

• Product Name: Benzoic acid, 3-methyl-, 2-(dithiocarboxy)hydrazide, monopotassium salt
• CAS NO: 85103-40-8
• Molecular Formula: C9H10N2OS2.K
• Molecular Weight: 264.414
• Mol File: 85103-40-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-methyl-, 2-(dithiocarboxy)hydrazide, monopotassium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-methyl-, 2-(dithiocarboxy)hydrazide, monopotassium salt(85103-40-8)
• EPA Substance Registry System: Benzoic acid, 3-methyl-, 2-(dithiocarboxy)hydrazide, monopotassium salt(85103-40-8)

Safety Data

• Hazardous Substances Data: 85103-40-8(Hazardous Substances Data)

Upstream product

• 120-33-2 ethyl 3-methylbenzoate 
• 1711-06-4 3-Methylbenzoyl chloride 
• 99-04-7 m-Toluic acid 
• 99-36-5 1-methoxycarbonyl-3-methylbenzene 
• 75-15-0 carbon disulfide 
• 13050-47-0 3-methylbenzoyl hydrazine 

Downstream Products

• 952901-20-1 C₁₅H₁₄N₄S 
• 85103-30-6 5-(3-methylphenyl)-1,3,4-thiadiazole-2-thiol 
• 66147-19-1 2-mercapto-5-(3-methylphenyl)-1,3,4-oxadiazole 
• 105576-60-1 4-amino-3-mercapto-5-(3-methylphenyl)-1,2,4-triazole 

Relevant articles and documents

Ultrasound-assisted, one-pot, three-component synthesis and antibacterial activities of novel indole derivatives containing 1,3,4-oxadiazole and 1,2,4-triazole moieties

Thirteen novel indole derivatives were efficiently synthesized through ultrasound irradiation by using 4-amino-5-(1H-indol-3-yl)-4H-[1,2,4]triazole-3-thiol (8) and 2-mercapto-5-substituted-1,3,4-oxadiazoles (5a-m). Compared with conventional and microwave methods, yields increased to 82-93%, and reaction times decreased to 15-35 min. The structures of these novel compounds were characterized by spectral data and elemental analysis. Two out of the synthesized compounds (10f and 10l) exhibited excellent activity against Staphylococcus aureus and Escherichia coli, and thus warrant further research.

Synthesis and evaluation of novel azoles as potent antifungal agents

Using a rational approach to the design of antifungal agents, a series of azole agents with 1,3,4-oxadiazole side chains were designed and synthesized. The results of preliminary in vitro antifungal tests with eight human pathogenic compounds showed that all of the title compounds exhibited excellent activities against all of the tested fungi except Aspergillus fumigatus. Compounds 11e and 11f were found to be the most effective, with a minimum inhibitory concentration of 0.0039 μg/mL, followed by voriconazole, which has a MIC of 0.0625 μg/mL. The 1,3,4-oxadiazole side chain is not the major contributor but plays a role in eliciting the observed antifungal activity.

Synthesis and antihyperlipidemic activity of some novel 4-(substitutedamino)-5-substituted-3-mercapto-(4H)-1,2,4-triazoles

Hyperlipidemia is considered one of the key factors for cardiovascular diseases. Based on earlier work on a series of 5-alkyl-4-aryl-3-mercapto-(4H)-1, 2,4-triazoles, for further lead modification, a series of 4-(substituted)amino- 5-substituted-3-mercapto-(4H)-1,2,4-triazoles was designed. Target compounds were synthesized by the well known Hoggarth synthesis of substituted 1,2,4-triazoles. Synthesized compounds were screened for lipid lowering activity using the "Poloxamer 407 induced hyperlipidemia in rats" model at a dose of 100 mg/kg p. o. Compounds were found to alter serum lipid levels significantly. Most of the compounds significantly reduced serum cholesterol and triglyceride levels. Some of the compounds were found to reduce triglycerides and elevate high density lipoprotein (HDL) levels more than the standard drug atorvastatin (CAS 134523-03-8). Compounds with chloro substitution on aryl rings were found more active in reducing serum lipid levels than other substitutions. ECV ? Editio Cantor Verlag.