851077-19-5

Basic information

• Product Name: Pyrimidine, 2-methyl-5-[4-(trifluoromethyl)phenyl]-
• CAS NO: 851077-19-5
• Molecular Formula: C12H9F3N2
• Molecular Weight: 238.212
• Mol File: 851077-19-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Pyrimidine, 2-methyl-5-[4-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 2-methyl-5-[4-(trifluoromethyl)phenyl]-(851077-19-5)
• EPA Substance Registry System: Pyrimidine, 2-methyl-5-[4-(trifluoromethyl)phenyl]-(851077-19-5)

Safety Data

• Hazardous Substances Data: 851077-19-5(Hazardous Substances Data)

Upstream product

• 7752-78-5 5-bromo-2-methylpyrimidine 
• 128796-39-4 4-trifluoromethylphenylboronic acid 

Downstream Products

• 851077-18-4 2-bromomethyl-5-(4-trifluoromethyl-phenyl)-pyrimidine 

Relevant articles and documents

Microwave-assisted synthesis of phenylpyrimidine derivatives via Suzuki-Miyaura reactions in water

An efficient method was developed to prepare biphenylpyrimidine scaffolds via a Suzuki-Miyaura coupling reaction. In this procedure, the products were synthesized under microwave irradiation in water and analogues of biguanidine were employed as ligands.

Phenyl derivatives, their manufacture and use as pharmaceutical agents

This invention relates to compounds of the formula wherein one of R5, R6 and R7 is and X1, X2, Y1 to Y4, R1 to R13 and m and n are defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.