851166-36-4

Basic information

• Product Name: N-phenyl-4-trifluoromethylbenzenecarbohydrazonoyl chloride
• Synonyms: N-phenyl-4-trifluoromethylbenzenecarbohydrazonoyl chloride
• CAS NO: 851166-36-4
• Molecular Weight: 298.695
• Mol File: 851166-36-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-phenyl-4-trifluoromethylbenzenecarbohydrazonoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenyl-4-trifluoromethylbenzenecarbohydrazonoyl chloride(851166-36-4)
• EPA Substance Registry System: N-phenyl-4-trifluoromethylbenzenecarbohydrazonoyl chloride(851166-36-4)

Safety Data

• Hazardous Substances Data: 851166-36-4(Hazardous Substances Data)

Upstream product

• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 100-63-0 phenylhydrazine 
• 455-19-6 4-Trifluoromethylbenzaldehyde 

Downstream Products

• 1251005-09-0 (3aR,6aR,3a'S,6a'S)-5,5'-[oxybis(4,1-phenylene)]bis[3a,6a-dihydro-1-phenyl-3-[4-(trifluoromethyl)phenyl]pyrrolo[3,4-c]pyrazole-4,6(1H,5H)-dione] 
• 1251005-22-7 (3aR,6aR,3a'S,6a'S)-5,5'-(1,4-phenylene)bis[3a,6a-dihydro-1-phenyl-3-[4-(trifluoromethyl)phenyl]pyrrolo[3,4-c]pyrazole-4,6(1H,5H)-dione] 
• 1251004-86-0 (3aR,6aR,3a'S,6a'S)-5,5'-[methylenebis(4,1-phenylene)]bis[3a,6a-dihydro-1-phenyl-3-[4-(trifluoromethyl)phenyl]pyrrolo[3,4-c]pyrazole-4,6(1H,5H)-dione] 
• 1232046-26-2 (3aR,6aR)-5,6a-dihydro-1-phenyl-5-[(1R)-1-phenylethyl]-3-[4-(trifluoromethyl)phenyl]pyrrolo[3,4-c]pyrazole-4,6(1H,3aH)dione 

Relevant articles and documents

Synthesis of 3 H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate

A nickel-promoted cascade annulation reaction for the facile synthesis of 3H-1,2,4-triazol-3-ones from readily available hydrazonoyl chlorides and sodium cyanate has been developed. The transformation occurs through a cascade nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence. The method has been successfully applied for the construction of the core skeleton of the angiotensin II antagonist.

Palladium-Catalyzed cascade carbonylative synthesis of 1,2,4-triazol-3-ones from hydrazonoyl chlorides and NaN3

A palladium-catalyzed three-component carbonylative reaction for the synthesis of 3H-1,2,4-triazol-3-ones from hydrazonoyl chlorides and NaN3 has been achieved. The reaction presumably proceeds through a cascade carbonylation, acyl azide format

Synthesis, UV-Vis spectra, and Hammett correlation of some novel bis(dihydropyrrolo[3,4-c]pyrazoles)

Twenty-nine novel bis(dihydropyrrolo[3,4-c]pyrazole) derivatives were obtained by reacting C, N-phenyl-substituted nitrilimines generated in situ from corresponding hydrazonyl chlorides with bismaleimides. The structures were elucidated by physical and spectroscopic methods [m.p., Rf, infrared (IR),1H nuclear magnetic resonance (NMR), 13C NMR, correlation spectroscopy (COSY), heteronuclear correlation (HETCOR), nuclear Overhauser effect (NOE), and high-resolution mass spectrometry (HRMS)]. Also, Hammett correlation graphs were obtained between Hammett constants σp and λmax values of bis(pyrrolopyrazoles) carrying p-substituted phenyl-ring-bearing electron-withdrawing and electrondonating groups and discussed in terms of substituent effects. Springer-Verlag 2010.