851172-88-8Relevant articles and documents
Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles
Herath, Ananda,Dahl, Russell,Cosford, Nicholas D.P.
supporting information; experimental part, p. 412 - 415 (2010/04/26)
[Chemical equation presented] The first continuous flow synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids directly from 2-aminopyridines and bromopyruvic acid has been developed, representing a significant advance over the corresponding in-flask method. The process was applied to the multistep synthesis of imidazo[1,2-a]pyridine-2-carboxamides, including a Mur ligase inhibitor, using a two microreactor, multistep continuous flow process without isolation of intermediates.