85150-03-4 Usage
Description
N-(2-Nitrophenyl)MethanesulfonaMide, also known as NIPS, is a chemical compound with the molecular formula C7H7N2O5S. It is a white to slightly yellow crystalline solid that is used as a reagent in organic synthesis, particularly in the preparation of peptides and pharmaceuticals. NIPS is known for its ability to protect and deprotect amino groups in organic reactions and is often used in peptide coupling reactions. It is also an important intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. NIPS is considered to be relatively stable under normal conditions, but it is important to handle it carefully and use appropriate safety precautions due to its potential toxicity and irritant properties.
Uses
Used in Organic Synthesis:
N-(2-Nitrophenyl)MethanesulfonaMide is used as a reagent for protecting and deprotecting amino groups in organic reactions, facilitating peptide coupling and enhancing the efficiency of organic synthesis processes.
Used in Pharmaceutical Industry:
N-(2-Nitrophenyl)MethanesulfonaMide is used as an intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving the manufacturing processes.
Used in Dye Industry:
N-(2-Nitrophenyl)MethanesulfonaMide is used as an intermediate in the synthesis of dyes, enabling the production of a wide range of colorants for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 85150-03-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,1,5 and 0 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 85150-03:
(7*8)+(6*5)+(5*1)+(4*5)+(3*0)+(2*0)+(1*3)=114
114 % 10 = 4
So 85150-03-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H8N2O4S/c1-14(12,13)8-6-4-2-3-5-7(6)9(10)11/h2-5,8H,1H3
85150-03-4Relevant articles and documents
Visible-Light-Mediated Nitration of Protected Anilines
Düsel, Simon J. S.,K?nig, Burkhard
, p. 2802 - 2807 (2018/03/09)
The photocatalytic nitration of protected anilines proceeds with riboflavin tetraacetate as an organic photoredox catalyst. Sodium nitrite serves as the NO2 source in this visible-light-driven room temperature reaction. Various nitroanilines are obtained in moderate to good yields without the addition of acid or stoichiometric oxidation agents. The catalytic cycle is closed by aerial oxygen as the terminal oxidant.
Mild hypervalent iodine mediated oxidative nitration of N-aryl sulfonamides
Kloeckner, Ulrich,Nachtsheim, Boris J.
, p. 10485 - 10487 (2014/09/29)
An oxidative and acid-free method for the nitration of N-aryl sulfonamides has been developed using a combination of sodium nitrite as cheap and easy to handle NO2-source and the hypervalent iodine reagent PIFA as stoichiometric oxidant. Under
PYRROLOPYRIMIDINES AS FAK AND ALK INHIBITERS FOR TREATMENT OF CANCERS AND OTHER DISEASES
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Page/Page column 104-105, (2012/04/23)
Disclosed are compounds which inhibit the activity of focal adhesion kinase (FAK) and anaplastic lymphoma kinase (ALK), compositions containing the compounds, and methods of treating diseases during which FAK and ALK are expressed. The diseases are, for example, cancers.
