85152-75-6Relevant articles and documents
Cobalt-Catalyzed Transfer Hydrogenation of α-Ketoesters and N-Cyclicsulfonylimides Using H2O as Hydrogen Source
Gao, Yang,Zhang, Xuexin,Laishram, Ronibala Devi,Chen, Jingchao,Li, Kangkui,Zhang, Keyang,Zeng, Guangzhi,Fan, Baomin
supporting information, p. 3991 - 3997 (2019/08/02)
A Co-catalyzed effective transfer hydrogenation of various α-ketoesters and N-cyclicsulfonylimides by safe and environmentally benign H2O as hydrogen source is described. The reaction used easily available and easy to handle zinc metal as a reductant. Interestingly, the catalytic system does not require ligand for reduction of N-cyclicsulfonylimides. (Figure presented.).
Synthesis method of pharmaceutical intermediate benzyl ester compound
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Paragraph 0042-0045, (2017/04/05)
The invention relates to a synthesis method of a benzyl ester compound capable of serving as a pharmaceutical intermediate and shown in a following formula (III). The synthesis method comprises the steps that a compound shown in the following formula (I) and a compound shown in the following formula (II) react in an organic solvent in the presence of a catalyst, an oxidant and an accelerant, and after the reaction is completed, after-treatment is performed so as to obtain the compound shown in the following formula (III) (show in the description), wherein R1 is selected from H, C1-C6 alkyls, C1-C6 alkoxys or halogens, R2 is selected from H, C1-C6 alkyls or halogens; R3 is selected from H or C1-C6 alkyls, and X represents halogen. The target product can be obtained by the adoption the method and through combined selection and coordination of the novel composite catalyst, the oxidant and the accelerant in a high-yield mode, and the brand new synthesis method is used for synthesis of the compound and has good application prospect and industrialized production potential on the aspect of pharmaceutical intermediate synthesis technologies.
Iron-Catalyzed Esterification of Benzyl C-H Bonds to Form α-Keto Benzyl Esters
He, Yue,Mao, Jincheng,Rong, Guangwei,Yan, Hong,Zhang, Guoqi
supporting information, p. 2125 - 2131 (2015/06/23)
An atom-economic and efficient non-precious metal-catalyzed esterification of benzyl C-H bonds has been developed. A variety of α-keto benzyl esters have been accessed in good yields through the reactions between benzyl derivatives and benzoylformic acids using iron trifluoride as a catalyst in the presence of di-tert-butyl peroxide under an inert atmosphere. This strategy provides a straightforward access to linearly expanded α-keto benzyl esters. A plausible reaction mechanism is proposed.
