85178-62-7 Usage
General Description
[(3S)-3-amino-3-carboxypropyl](hydroxy)oxophosphonium, also known as ACP, is a small molecule derivative of pyruvate that has been identified as an intermediate in the catalytic conversion of pyruvate to acetyl phosphate by pyruvate phosphate dikinase (PPDK), a key enzyme involved in carbon metabolism in plants and bacteria. ACP plays a crucial role in the pyruvate phosphate dikinase reaction by serving as a phosphoryl donor during the conversion of pyruvate to phosphoenolpyruvate (PEP), a key step in the process of gluconeogenesis. ACP is essential for the efficient utilization of pyruvate by PPDK and is therefore of great interest as a potential target for the development of novel antibiotics and herbicides that aim to disrupt carbon metabolism in pathogenic bacteria and agricultural pests. Further research on ACP and its role in carbon metabolism may lead to a better understanding of metabolic pathways and the development of new strategies for controlling infectious diseases and agricultural pests.
Check Digit Verification of cas no
The CAS Registry Mumber 85178-62-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,1,7 and 8 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 85178-62:
(7*8)+(6*5)+(5*1)+(4*7)+(3*8)+(2*6)+(1*2)=157
157 % 10 = 7
So 85178-62-7 is a valid CAS Registry Number.
85178-62-7Relevant articles and documents
Convenient syntheses of phosphinic analogues of γ-aminobutyric- and glutamic acids
Khomutov,Formanovsky,Mikhura,Vepsalainen,Kochetkov,De Biase,Khomutov
, p. 672 - 676 (2017/01/28)
Three-steps, one-pot synthesis of 2-amino-4-(hydroxyphosphinyl)butyric acid from dibutyl ester of vinylphosphinic acid was carried out with an overall yield of 66%. 3-Aminopropylphosphinic acid was prepared from allylamine in three steps with an overall y
L-(+)-2-amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: Increased distal acidity affords enhanced potency
Selvam, Chelliah,Goudet, Cyril,Oueslati, Nadia,Pin, Jean-Philippe,Acher, Francine C.
, p. 4656 - 4664 (2008/03/12)
L-2-Amino-4-phosphonobutyric acid (L-AP4), L-2-amino-4-thiophosphonobutyric acid (L-thioAP4), and L-2-amino-4-(hydroxy)phosphinylbutyric acid (desmethylphosphinothricin, DMPT) were synthesized from protected vinylglycine. They were tested as agonists at g
SYNTHESIS AND PROPERTIES OF PHOSPHINOTRICIN DERIVATIVES
Maier, Ludwig,Rist, Guenter,Lea, Peter J.
, p. 349 - 352 (2007/10/02)
The synthesis and properties of phosphinotricin derivatives which have different alkyl groups attached to phosphorus or bear a substituent on the nitrogen are described and their biological activities discussed.
