851895-79-9

Basic information

• Product Name: (3beta)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol 3-acetate
• Synonyms: (3beta)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol 3-acetate;(3S,8R,9S,10R,13S,14S)-17-(1H-benzo[d]iMidazol-1-yl)-10,13-diMethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate;(3S,8R,9S,10R,13S)-17-(1H-benzo[d]imidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate
• CAS NO: 851895-79-9
• Molecular Formula: C28H34N2O2
• Molecular Weight: 430.58176
• Mol File: 851895-79-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 159-160℃
• Appearance: /
• Density: 1.26
• CAS DataBase Reference: (3beta)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol 3-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (3beta)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol 3-acetate(851895-79-9)
• EPA Substance Registry System: (3beta)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol 3-acetate(851895-79-9)

Safety Data

• Hazardous Substances Data: 851895-79-9(Hazardous Substances Data)

Usage

Description

(3beta)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol 3-acetate, also known as benzimidazole androsta, is a synthetic compound belonging to the class of androstanes. It is a derivative of androstenol, a pheromone found in humans and animals, with a benzimidazole group attached to the 17th carbon and an acetate group attached to the 3rd carbon. This chemical has been studied for its potential medical applications, including its role as an anti-inflammatory and analgesic agent.

Uses

Used in Pharmaceutical Industry:
(3beta)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol 3-acetate is used as an anti-inflammatory and analgesic agent for its potential to reduce inflammation and alleviate pain.
Used in Hormone Replacement Therapy:
(3beta)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol 3-acetate is used as a hormone replacement therapy agent for its potential to address hormonal imbalances and related conditions.
Used in Oncology:
(3beta)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol 3-acetate is used as a potential treatment for certain types of cancers, as it has been studied for its possible anti-cancer properties.

Upstream product

• 1865-56-1 3β-acetoxy-17-chloro-16-formylandrost-5,16-diene 
• 51-17-2 benzoimidazole 
• 851895-78-8 3-β-acetoxy-17-(1H-benzimidazol-1-yl)-16-formyl-androsta-5,16-diene 

Downstream Products

• 1441047-09-1 3β-(6-(cyclohex-3-enecaboxylic acid)carboxylate)-17-(1H-benzimidazol-1-yl)-androsta-5,16-diene 
• 1441047-08-0 3β-(3-(oxycarbonyl)phenylacetic acid)-17-(1H-benzimidazol-1-yl)-androsta-5,16-diene 
• 1441047-00-2 3β-tosyloxy-17-(1H-benzimidazol-1-yl)-androsta-5,16-diene 
• 851983-85-2 Galeterone 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF GALETERONE

A process for the synthesis of 3β-hydroxy-17-(1H-benzimidazol-1-yl)androsta-5,16-diene is described, a compound also known as Galeterone and used in the treatment of prostate cancer, having the formula (I) given below.

BIOMARKERS FOR TREATMENT OF NEOPLASTIC DISORDERS USING ANDROGEN-TARGETED THERAPIES

Described herein are methods and compositions for the treatment of prostate cancer in a subject in need thereof. The prostate cancer may be a castration resistant and an androgen receptor antagonist-resistant prostate cancer. The methods may comprise administering to the subject a CYP17-lyase inhibitor of Formula II.

ANDROGEN RECEPTOR DOWN-REGULATING AGENTS AND USES THEREOF

The present disclosure provides the design and synthesis of novel steroidal compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant. The compounds are potential agents for the treatment of all forms of prostate cancer and other diseases that depend on functional AR.