851912-61-3

Basic information

• Product Name: 3-Pyrrolidinol, 1-(6-amino-1-oxohexyl)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]- , (3R,5S)-
• CAS NO: 851912-61-3
• Molecular Formula: C32H40N2O5
• Molecular Weight: 532.68
• Mol File: 851912-61-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-Pyrrolidinol, 1-(6-amino-1-oxohexyl)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]- , (3R,5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyrrolidinol, 1-(6-amino-1-oxohexyl)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]- , (3R,5S)-(851912-61-3)
• EPA Substance Registry System: 3-Pyrrolidinol, 1-(6-amino-1-oxohexyl)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]- , (3R,5S)-(851912-61-3)

Safety Data

• Hazardous Substances Data: 851912-61-3(Hazardous Substances Data)

Upstream product

• 407-91-0 6-(trifluoroacetamido)hexanoic acid 
• 60-32-2 6-aminohexanoic acid 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 151953-64-9 (3R,5S)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}pyrrolidine-3-ol 
• 4443-26-9 6-phthalimidohexanoic acid 
• 1947-00-8 6-(benzyloxycarbonylamino)hexanoic acid 
• 95687-41-5 (2S,4R)-N1-(benzyloxycarbonyl)-4-hydroxy-2-(hydroxymethyl)-pyrrolidine 
• 478922-47-3 (3R,5S)-5-(hydroxymethyl)pyrrolidin-3-ol hydrochloride 
• 117032-51-6 N-ε-trifluoroacetylaminohexanoic acid N-hydroxysuccinimide ester 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 

Downstream Products

• 1257063-26-5 C₅₅H₆₁N₃O₈ 
• 1257063-22-1 C₃₈H₄₆N₂O₆ 
• 1257063-27-6 C₆₄H₇₈N₅O₉P 

Relevant articles and documents

Phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the synthesis of modified oligonucleotides

The synthesis of phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the introduction of the residues of biotin, lipoic acid, amino groups, and terminal acetylene groups at different positions of the oligonucleotide chain has been described. The efficiency of the reagents and supports has been confirmed by the synthesis of the corresponding modified oligonucleotides.

COMPOSITIONS AND METHODS FOR MODULATING GROWTH HORMONE RECEPTOR EXPRESSION

The present embodiments provide methods, compounds, and compositions for treating, preventing, ameliorating a disease associated with excess growth hormone using antisense compounds oligonucleotides targeted to growth hormone receptor (GHR).

OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION

The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.