85198-69-2Relevant articles and documents
Stereoselective Introduction of Steroid Side Chains. Synthesis of Chenodeoxycholic Acid
Wovkulich, Peter M.,Batcho, Andrew D.,Uskokovic, Milan R.
, p. 612 - 615 (1984)
A new short route to chenodeoxycholic acid has been developed.The synthesis is based on the stereoselective introduction of the steroidal side chain via an ene reaction of methyl acrylate and a (17Z)-ethylidene steroid prepared from androstenedione.
Process and intermediates for the synthesis of Vitamin D3 metabolites and chenodeoxycholic acid
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, (2008/06/13)
The present disclosure is directed to a process for the synthesis of chenodeoxychloic acid, 25-hydroxycholesterol and 1α,25-dihydroxycholesterol from 17-keto steroids. A cholic acid side chain is stereospecifically introduced by reaction of the appropriate 17-keto steroid with ethyltriphenylphosphonium halides to produce the 17-ethylidene derivative which is allowed to react with acrylic acid esters or propiolic acid esters followed by hydrogenation.
