85231-15-8

Basic information

• Product Name: 4-Hydroxy-2,5-dimethylbenzaldehyde
• Synonyms: 4-HYDROXY-2,5-DIMETHYL-BENZALDEHYDE;4-Formyl-2,5-dimethylphenol ;2,5-dimethyl-4-hydroxybenzaldehyde;Benzaldehyde,4-hydroxy-2,5-diMethyl-
• CAS NO: 85231-15-8
• Molecular Formula: C₉H₁₀O₂
• Molecular Weight: 150.17
• Product Categories: pharmacetical
• Mol File: 85231-15-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 272.669 °C at 760 mmHg
• Flash Point: 113.798 °C
• Appearance: /
• Density: 1.137 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-Hydroxy-2,5-dimethylbenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-2,5-dimethylbenzaldehyde(85231-15-8)
• EPA Substance Registry System: 4-Hydroxy-2,5-dimethylbenzaldehyde(85231-15-8)

Safety Data

• Hazardous Substances Data: 85231-15-8(Hazardous Substances Data)

Usage

Uses

4-Hydroxy-2,5-dimethylbenzaldehyde

Upstream product

• 95-87-4 2,5-Dimethylphenol 
• 93-61-8 N-methyl-N-phenylformamide 
• 4885-02-3 Dichloromethyl methyl ether 
• 20524-86-1 dichloromethyl ether 
• 6745-75-1 2,5-dimethyl-p-anisaldehyde 
• 95-78-3 2,5-Dimethylaniline 
• 576-26-1 2.6-dimethylphenol 
• 67-66-3 chloroform 
• 7446-70-0 aluminium trichloride 
• 74-90-8 hydrogen cyanide 
• 71-43-2 benzene 
• 10496-93-2 4-Hydroxy-2,5-dimethylbenzenemethanol 
• 60431-06-3 1-<(4-Hydroxy-3,5-dimethyl-phenyl)-methyl>-pyrrolidin 
• 16819-05-9 N-<(4-Hydroxy-3,6-dimethyl-phenyl)-methyl>-dimethylamin 

Downstream Products

• 936712-23-1 2-(4-formyl-2,5-dimethyl-phenoxy)-2-methyl-propionic acid methyl ester 
• 852947-74-1 2,5-dimethyl-4-triisopropylsilanyloxy-benzaldehyde 
• 18073-33-1 6-methylellipticine 
• 90609-92-0 4-hydroxy-2,5-dimethyl-benzaldehyde-oxime 
• 496-78-6 2,4,5-trimethylphenol 
• 6745-75-1 2,5-dimethyl-p-anisaldehyde 
• 52670-13-0 2-(4-methoxy-2,5-dimethylphenyl)ethanamine 

Relevant articles and documents

A transition metal-free approach to a regioselective total synthesis of the natural product derivative 6-methylellipticine, a potent anticancer agent

A transition metal-free and regioselective total synthesis of 6-methylellipticine, a potent anticancer agent, was developed. This synthetic approach mainly involved two key reactions: a direct amination of multi-functional phenol via an alkylation-Smiles

Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors

Inhibition of sphingosine-1-phosphate lyase has recently been proposed as a potential treatment option for inflammatory disorders such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. In this report we describe our hit-to-lead evaluation of the isoxazolecarboxamide 6, a high-throughput screening hit (in vitro IC50 = 1.0 μM, cell IC50 = 1.8 μM), as a novel S1P lyase inhibitor. We were able to establish basic structure-activity relationships around 6 and succeeded in obtaining X-ray structural information which enabled structure-based design. With the discovery of 28, enzyme activity was quickly improved to IC50 = 120 nM and cell potency to IC50 = 230 nM. The main liability in the established isoxazolecarboxamide hit series was determined to be metabolic stability. In particular we identified that future lead-optimization efforts to overcome this problem should focus on blocking the N-dealkylation on the secondary amine.

Novel Phosphinic Acid-Containing Thyromimetics

The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.