852391-55-0

Basic information

• Product Name: L-Tryptophan, N-acetyl-7-chloro-
• CAS NO: 852391-55-0
• Molecular Formula: C13H13ClN2O3
• Mol File: 852391-55-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Tryptophan, N-acetyl-7-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tryptophan, N-acetyl-7-chloro-(852391-55-0)
• EPA Substance Registry System: L-Tryptophan, N-acetyl-7-chloro-(852391-55-0)

Safety Data

• Hazardous Substances Data: 852391-55-0(Hazardous Substances Data)

Upstream product

• 77290-47-2 N-Acetyl-7-chlor-DL-tryptophan 

Downstream Products

• 153-97-9 7-chloro-L-tryptophan 
• 852391-20-9 (S)-5-(7'-Chloro-1H-indol-3ylmethyl)-3-methyl-imidazolidine-2,4-dione 

Relevant articles and documents

Structure-activity relationship study of novel necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-α. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). A SAR study revealed that several positions of the indole were intolerant of substitution, while small substituents at the 7-position resulted in increased inhibitory activity. The hydantoin ring was also quite sensitive to structural modifications. A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration.