852569-35-8

Basic information

• Product Name: 4-amino-5-iodo-2-(trifluoromethyl)benzonitrile
• Synonyms: 4-amino-5-iodo-2-(trifluoromethyl)benzonitrile;4-Amino-5-iodo-2-(trifluoromethyl)-benzenecarbonitrile;4-amino-2-(trifluoromethyl)-5-iodobenzonitrile
• CAS NO: 852569-35-8
• Molecular Formula: C₈H₄F₃IN₂
• Molecular Weight: 312.03
• Product Categories: Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 852569-35-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 170-172°
• Boiling Point: 329.5±42.0 °C(Predicted)
• Appearance: /
• Density: 2.00±0.1 g/cm3(Predicted)
• PKA: -1.56±0.10(Predicted)
• CAS DataBase Reference: 4-amino-5-iodo-2-(trifluoromethyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-5-iodo-2-(trifluoromethyl)benzonitrile(852569-35-8)
• EPA Substance Registry System: 4-amino-5-iodo-2-(trifluoromethyl)benzonitrile(852569-35-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 852569-35-8(Hazardous Substances Data)

Upstream product

• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 

Downstream Products

• 1131623-15-8 4-amino-5-hydroxy-2-(trifluoromethyl)benzonitrile 
• 1354948-13-2 4-[5-(chloromethyl)-1H-tetrazol-1-yl]-5-methyl-2-(trifluoromethyl)benzonitrile 
• 1354948-12-1 4-[5-(hydroxymethyl)-1H-tetrazol-1-yl]-5-methyl-2-(trifluoromethyl)benzonitrile 
• 1354948-11-0 {1-[4-cyano-2-methyl-5-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl acetate 
• 1354948-10-9 2-{[4-cyano-2-methyl-5-(trifluoromethyl)phenyl]amino}-2-oxoethyl acetate 
• 875056-26-1 4-amino-5-methyl-2-trifluoromethylbenzonitrile 
• 868692-62-0 N-(4-cyano-2-iodo-5-trifluoromethyl-phenyl)-methanesulfonamide 
• 888072-96-6 4-amino-5-cyano-2-trifluoromethyl-benzonitrile 
• 868690-65-7 2-[2-(4-fluoro-phenylsulfanyl)-1-hydroxy-1-methyl-ethyl]-6-trifluoromethyl-1H-indole-5-carbonitrile 
• 888073-00-5 N-(4-cyano-2-ethylsulfanyl-5-trifluoromethyl-phenyl)-2-methyl-acrylamide 
• 888072-97-7 N-(2,4-dicyano-5-trifluoromethyl-phenyl)-2-methyl-acrylamide 
• 888073-07-2 N-(4-cyano-2-methoxy-5-trifluoromethyl-phenyl)-2-methyl-acrylamide 
• 888072-94-4 N-(4-cyano-2-ethyl-5-trifluoromethyl-phenyl)-2-methyl-acrylamide 
• 949513-12-6 4-amino-5-ethynyl-2-trifluoromethyl-benzonitrile 

Relevant articles and documents

The discovery of a potent orally efficacious indole androgen receptor antagonist through in vivo screening

A series of novel 2-(1H-indol-2-yl)-propan-2-ols have been designed, synthesized, and screened for their ability to inhibit testosterone-induced prostate weight increases in immature rats. Through the use of this paradigm, we were able to identify compoun

A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands

Two potential bioisosteres of the nonsteroidal antiandrogen bicalutamide, an imidazolidinone and an indole, were synthesized and tested for their androgen receptor binding. Indole was discovered to be a suitable bioisostere for the acyl anilide moiety in the parent compound. Several analogs in the indole series were found to be 10-fold better than bicalutamide in binding to the recombinant androgen receptor binding domain.

Novel indole derivatives as selective androgen receptor modulators (SARMS)

The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.