852690-16-5Relevant articles and documents
Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT
Barreca, Maria Letizia,Rao, Angela,De Luca, Laura,Zappalà, Maria,Monforte, Anna-Maria,Maga, Giovanni,Pannecouque, Christophe,Balzarini, Jan,De Clercq, Erik,Chimirri, Alba,Monforte, Pietro
, p. 3433 - 3437 (2007/10/03)
A three-dimensional common feature pharmacophore model was developed using the X-ray structure of RT/non-nucleoside inhibitor (NNRTI) complexes. Starting from the pharmacophore hypothesis and the structure of the lead compound TBZ, new NNRTIs were designe