85277-78-7

Basic information

• Product Name: ethyl (E)-3-fluoro-2-phenylacrylate
• Synonyms: ethyl (E)-3-fluoro-2-phenylacrylate
• CAS NO: 85277-78-7
• Molecular Weight: 194.206
• Mol File: 85277-78-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ethyl (E)-3-fluoro-2-phenylacrylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (E)-3-fluoro-2-phenylacrylate(85277-78-7)
• EPA Substance Registry System: ethyl (E)-3-fluoro-2-phenylacrylate(85277-78-7)

Safety Data

• Hazardous Substances Data: 85277-78-7(Hazardous Substances Data)

Upstream product

• 85278-32-6 ethyl 2-phenyl-3,3-difluoroacrylate 
• 22065-57-2 ethyl 2-phenyldiazoacetate 
• 17097-90-4 2-phenylmalonic acid monoethyl ester 
• 101-97-3 Ethyl 2-phenylethanoate 
• 85277-62-9 ethyl 2-(tert-butoxycarbonyl)phenylacetate 
• 16537-09-0 t-butyl phenylacetate 

Relevant articles and documents

Stereoselective Palladium-Catalyzed C?F Bond Alkynylation of Tetrasubstituted gem-Difluoroalkenes

A stereoselective Pd(PPh3)4-catalyzed C?F bond alkynylation of tetrasubstituted gem-difluoroalkenes with terminal alkynes has been developed. This method gives access to a great variety of conjugated monofluoroenynes bearing a tetrasubstituted alkene moiety with well-defined stereochemistry. Chelation-assisted oxidative addition of Pd to the C?F bond is proposed to account for the high level of stereocontrol. An X-ray crystal structure of a key monofluorovinyl PdII intermediate has been obtained for the first time as evidence for the proposed mechanism.

Palladium-Catalyzed Stereoselective Hydrodefluorination of Tetrasubstituted gem-Difluoroalkenes

A highly stereoselective palladium(0)-catalyzed hydrodefluorination (HDF) of tetrasubstituted gem-difluoroalkenes is developed. By using catalytic Pd(PPh3)4 (2.5-5 mol percent) and hydrosilane Me2PhSiH, various trisubstituted terminal (E)-monofluoroalkenes can be synthesized with excellent E/Z selectivity (>99:1) and good functional group tolerability. The key stereocontrol should be exerted by an ester-directed C-F bond oxidative addition step in the catalytic cycle.

Enzyme-activated irreversible inhibitors of monoamine oxidase: Phenylallylamine structure-activity relationships

Seventeen 2-aryl-3-haloallylamine derivatives were prepared and evaluated as inhibitors of monoamine oxidase (MAO, EC 1.4.3.4). The synthesis of these compounds was achieved from either α-methylstyrene or ring-substituted phenylacetic acid derivatives. Wi