85386-99-8

Basic information

• Product Name: 2-CHLORO-3-(PIPERAZINYL)PYRAZINE
• Synonyms: 2-CHLORO-3-(PIPERAZINYL)PYRAZINE;2-CHLORO-3-(1-PIPERAZINYL)PYRAZINE;2-Chloro-3-(piperazin-1-yl)
• CAS NO: 85386-99-8
• Molecular Formula: C₈H₁₁ClN₄
• Molecular Weight: 198.65274
• Mol File: 85386-99-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 342.684°C at 760 mmHg
• Flash Point: 161.05°C
• Appearance: /
• Density: 1.272g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: 2-8°C
• PKA: 8.11±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-3-(PIPERAZINYL)PYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-(PIPERAZINYL)PYRAZINE(85386-99-8)
• EPA Substance Registry System: 2-CHLORO-3-(PIPERAZINYL)PYRAZINE(85386-99-8)

Safety Data

• Hazardous Substances Data: 85386-99-8(Hazardous Substances Data)

Usage

General Description

2-CHLORO-3-(PIPERAZINYL)PYRAZINE is a chemical compound that consists of a pyrazine ring with a chlorine atom at position two and a piperazine ring attached at position three. It is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The compound has potential applications in medicine due to its ability to act as a building block for developing new drugs. Additionally, it may also be used in the production of insecticides and herbicides. 2-CHLORO-3-(PIPERAZINYL)PYRAZINE is considered to be a valuable chemical with various industrial uses.

InChI:InChI=1/C8H11ClN4/c9-7-8(12-2-1-11-7)13-5-3-10-4-6-13/h1-2,10H,3-6H2

Upstream product

• 313654-83-0 2-Chloro-3-(4-tert-butoxycarbonyl-1-piperazinyl)pyrazine 

Downstream Products

• 313658-24-1 2-[3-(2-Methoxyphenyl)propoxy]-3-(1-piperazinyl)pyrazine, Maleate 
• 313658-82-1 2-[(4-Methoxybenzyl)oxy]-3-(1-piperazinyl)pyrazine 
• 313658-26-3 2-{[(2E)-3-(2-Methoxyphenyl)-2-propenyl]oxy}-3-(1-piperazinyl)pyrazine, Maleate 
• 1082063-65-7 methyl 4-(3-(4-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)pyrazin-2-yl)benzoate hydrochloride 
• 1082063-19-1 2-{4-[3'-(4-methoxymethyl-phenyl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-ylmethyl]-pyrazol-1-yl}-ethanol hydrochloride 
• 1377551-31-9 C₁₄H₁₄BrClN₄O₂S 

Relevant articles and documents

NOVEL COMPOUNDS AS ROR GAMMA MODULATORS

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

SUBSTITUTED PIPERAZINYL PYRAZINES AND PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS

The present invention provides selective 5-HT7 receptor antagonist compounds of Formula (I) and their use in the treatment of migraine: where A is C(H)= or N=; m is 0, 1 or 2; R1 is optionally substituted phenyl, optionally substituted pyrazol-4-yl; optionally substituted imidazolyl, optionally substituted pyridyl, or thienyl; R2 is hydrogen or methyl; and R3 and R4 are as defined herein.

2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS

The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently C(H)= or N=, provided that at least one of A and B is -N=, n is 1-3, m is 0-3, and R14 are as defined herein.