854892-34-5

Basic information

• Product Name: CYCLOHEXYL 3,4-DICHLOROPHENYL KETONE
• Synonyms: CYCLOHEXYL 3,4-DICHLOROPHENYL KETONE;OTAVA-BB 1044144
• CAS NO: 854892-34-5
• Molecular Formula: C₁₃H₁₄Cl₂O
• Molecular Weight: 257.16
• Mol File: 854892-34-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 378.296°C at 760 mmHg
• Flash Point: 159.942°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: CYCLOHEXYL 3,4-DICHLOROPHENYL KETONE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOHEXYL 3,4-DICHLOROPHENYL KETONE(854892-34-5)
• EPA Substance Registry System: CYCLOHEXYL 3,4-DICHLOROPHENYL KETONE(854892-34-5)

Safety Data

• Hazardous Substances Data: 854892-34-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H14Cl2O/c14-11-7-6-10(8-12(11)15)13(16)9-4-2-1-3-5-9/h6-9H,1-5H2

Upstream product

• 6287-38-3 3,4-dichlorobenzaldehyde 
• 931-51-1 cyclohexylmagnesiumchloride 
• 1025918-21-1 Cyclohexyl-(3,4-dichloro-phenyl)-methanol 
• 151169-75-4 3,4-dichlophenylboronic acid 
• 2719-27-9 cyclohexanylcarbonyl chloride 

Downstream Products

• 847448-21-9 {[cyclohexyl-(3,4-dichloro-phenyl)-methyl]-formyl-amino}-acetic acid methyl ester 
• 868396-39-8 3-cyclohexyl-3-(3,4-dichloro-phenyl)-3-hydroxy-1-piperidin-1-yl-propan-1-one 

Relevant articles and documents

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain

Herein we report the synthesis and evaluation of a series of thiosemicarbazones as potential inhibitors of cysteine proteases relevant to parasitic diseases. Derivatives of thiosemicarbazone 1 were discovered to be potent inhibitors of cruzain and rhodesain, crucial proteases in the life cycles of Trypanosoma cruzi and T. brucei rhodesiense, the organisms causing Chagas' disease and sleeping sickness. However, the entire series had only modest potency against falcipain-2, an essential protease for Plasmodium falciparum, the organism causing malaria. Among the active inhibitors, several potently inhibited proliferation of cultures of T. brucei. However, only modest activity was observed in inhibition of proliferation of T. cruzi or P. falciparum. Herein we report the synthesis and evaluation of a series of thiosemicarbazones as potential inhibitors of cysteine proteases relevant to parasitic diseases. Derivatives of thiosemicarbazone 1 were discovered to be potent inhibitors of cruzain and rhodesain, crucial proteases in the life cycles of Trypanosoma cruzi and T. brucei rhodesiense, the organisms causing Chagas' disease and sleeping sickness. However, the entire series had only modest potency against falcipain-2, an essential protease for Plasmodium falciparum, the organism causing malaria. Among the active inhibitors, several potently inhibited proliferation of cultures of T. brucei. However, only modest activity was observed in inhibition of proliferation of T. cruzi or P. falciparum.