855196-51-9

Basic information

• Product Name: 4-(propylthio)benzonitrile
• Synonyms: 4-(propylthio)benzonitrile
• CAS NO: 855196-51-9
• Molecular Weight: 177.27
• Mol File: 855196-51-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-(propylthio)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(propylthio)benzonitrile(855196-51-9)
• EPA Substance Registry System: 4-(propylthio)benzonitrile(855196-51-9)

Safety Data

• Hazardous Substances Data: 855196-51-9(Hazardous Substances Data)

Upstream product

• 540-54-5 1-Chloropropane 
• 6068-72-0 4-cyanobenzoyl chlorIde 
• 26891-63-4 1-propyl-2'-thiopyridine 
• 619-65-8 4-cyanobenzoic Acid 
• 1194-02-1 4-fluorobenzonitrile 
• 6898-84-6 sodium 1-propanethiolate 
• 49584-26-1 p-cyanobenzenesulfonyl chloride 
• 623-00-7 4-bromobenzenecarbonitrile 
• 22133-40-0 4-aminophenyl propyl sulphide 
• 151-50-8 potassium cyanide 

Downstream Products

• 855290-50-5 4-(propylsulfonyl)benzonitrile 
• 857489-11-3 4-propylsulfanyl-benzoic acid amide 
• 22683-48-3 4-(propylthio)benzoic acid 

Relevant articles and documents

Ni-Catalyzed Aryl Sulfide Synthesis through an Aryl Exchange Reaction

A Ni-catalyzed aryl sulfide synthesis through an aryl exchange reaction between aryl sulfides and a variety of aryl electrophiles was developed. By using 2-pyridyl sulfide as a sulfide donor, this reaction achieved the synthesis of aryl sulfides without using odorous and toxic thiols. The use of a Ni/dcypt catalyst capable of cleaving and forming aryl-S bonds was important for the aryl exchange reaction between 2-pyridyl sulfides and aryl electrophiles, which include aromatic esters, arenol derivatives, and aryl halides. Mechanistic studies revealed that Ni/dcypt can simultaneously undergo oxidative additions of aryl sulfides and aromatic esters, followed by ligand exchange between the generated aryl-Ni-SR and aryl-Ni-OAr species to furnish aryl exchanged compounds.

CuI promoted sulfenylation of organozinc reagents with arylsulfonyl chlorides

A CuI promoted sulfenylation of organozinc reagents with arylsulfonyl chlorides/PPh3 has been explored. This reaction proceeded smoothly through an alkyl/aryl radical (generated from organometallics) under mild conditions and produced the desired sulfide products in excellent yields.

THERAPEUTIC AGENTS

A compound of the formula (I): wherein R1,R2,R3, R4,Ar, A, n and m are defined herein, is disclosed as a GlyT1 inhibitor; pharmaceutical compositions containing the compound of the formula (I) are also disclosed as are their use in medicine, for example in the treatment of schizophrenia.