85547-22-4 Usage
Description
8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE is a chemical compound belonging to the class of benzo[a]naphtho[de][1,6]naphthyridines. It is characterized by the presence of two methoxy groups at the 8th and 9th positions, which contribute to its unique chemical properties and potential applications.
Uses
Used in Pharmaceutical Industry:
8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE is used as a pharmaceutical agent for its potential therapeutic effects. As a spongean alkaloid, it can activate the p21 promoter in the absence of p53, which may have implications for the treatment of certain types of cancer. Additionally, it functions as a proteasome inhibitor, which can help regulate cellular processes and potentially lead to the development of new treatments for various diseases.
Used in Research Applications:
8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE is also used as a research tool in the field of chemistry and biology. Its unique structure and properties make it a valuable compound for studying the interactions between molecules and understanding the mechanisms of various biological processes. This can contribute to the advancement of scientific knowledge and the development of new drugs and therapies.
Synthesis Reference(s)
The Journal of Organic Chemistry, 52, p. 616, 1987 DOI: 10.1021/jo00380a024Tetrahedron Letters, 31, p. 569, 1990 DOI: 10.1016/0040-4039(90)87037-Z
Check Digit Verification of cas no
The CAS Registry Mumber 85547-22-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,5,4 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 85547-22:
(7*8)+(6*5)+(5*5)+(4*4)+(3*7)+(2*2)+(1*2)=154
154 % 10 = 4
So 85547-22-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H12N2O2/c1-16-10-7-8-3-5-14-9-4-6-15-12(11(8)9)13(10)17-2/h3-7,15H,1-2H3
85547-22-4Relevant articles and documents
Synthesis of aaptamine, a novel marine alkaloid
Pelletier,Cava
, p. 1259 - 1260 (1985)
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AAPTAMINE ALKALOID DERIVATIVES AND SYNTHESIS METHOD AND APPLICATION THEREOF
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Paragraph 0033; 0037, (2019/12/01)
A benzodiazepine alkaloid compound and a pharmaceutically acceptable salt thereof, the structure of the compound being shown in general formula (I). in the formula (I), R1, R2 and R3 independently are hydrogen, C1-4
A SYNTHESIS OF AAPTAMINE FROM 6,7-DIMETHOXY-1-METHYLISOQUINOLINE
Batczewski, Piotr,Mallon, M. Kieran J.,Street, Jonathan D.,Joule, John A.
, p. 3193 - 3198 (2007/10/02)
6,7-Methoxy-1-methylisoquinoline 3a was nitratwd at C-8, oxidised to thenitro aldehyde 3r and then condensed with nitromethane using alumina as base to give the alcohol 3s, dehydration of which produced the nitroethene 3t.Iron-acetic acid treatment of com
