855785-98-7

Basic information

• Product Name: (1R)-3-(3,5-difluorophenyl)-2-(carboxymethyl)trop-2-ene
• Synonyms: (1R)-3-(3,5-difluorophenyl)-2-(carboxymethyl)trop-2-ene
• CAS NO: 855785-98-7
• Molecular Weight: 293.313
• Mol File: 855785-98-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R)-3-(3,5-difluorophenyl)-2-(carboxymethyl)trop-2-ene(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-3-(3,5-difluorophenyl)-2-(carboxymethyl)trop-2-ene(855785-98-7)
• EPA Substance Registry System: (1R)-3-(3,5-difluorophenyl)-2-(carboxymethyl)trop-2-ene(855785-98-7)

Safety Data

• Hazardous Substances Data: 855785-98-7(Hazardous Substances Data)

Upstream product

• 156545-07-2 3,5-difluorophenylboronic acid 
• 168143-65-5 methyl (1R,5S)-8-methyl-3-(((trifluoromethyl)sulfonyl)oxy)-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate 
• 156856-80-3 (+)-(Methoxycarbonyl)tropinone 

Downstream Products

• 855848-97-4 (1R)-3α-(3,5-difluorophenyl)tropane-2β-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis and monoamine transporter binding properties of 3α-(substituted phenyl)nortropane-2β-carboxylic acid methyl esters. Norepinephrine transporter selective compounds

3α-(Substituted phenyl)nortropane-2β-carboxylic acid methyl esters (8a-h) showed high affinity for the norepinephrine transporter (NET). The most potent and selective compound was 3α-(3-fluoro-4-methylphenyl) nortropane-2β-carboxylic acid methyl ester (8d), with a Ki of 0.43 nM at the NET and 21- and 55-fold selectivity relative to binding at the dopamine and serotonin transporters. The development of 8d makes available compounds selective for all three transporters from the same structural class.