855839-06-4Relevant articles and documents
Synthesis, biological evaluation and molecular docking studies of bis-chalcone derivatives as xanthine oxidase inhibitors and anticancer agents
Burmaoglu, Serdar,Ozcan,Balcioglu,Gencel,Noma, Samir Abbas Ali,Essiz, Sebnem,Ates, Burhan,Algul, Oztekin
, (2019)
In this study, a series of B-ring fluoro substituted bis-chalcone derivatives were synthesized by Claisen-Schmidt condensation reactions and evaluated for their ability to inhibit xanthine oxidase (XO) and growth inhibitory activity against MCF-7 and Caco
Multi-substituted aromatic diketone compound and its preparation method and application (by machine translation)
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Paragraph 0094-0098, (2017/02/28)
The invention of the formula (I) of the said multi-substituted aromatic diketone compound and its preparation and application. Formula (I) in R 1 formula (I-1), type (I-2) or a formula (I-3) substituent, R 2 to-H, -F, -Cl, -Br, -CH 3 or-OCH 3. When the R 1 formula (I-1) time, the method of the invention is to 2,4-di-hydroxy acetophenone as raw materials, and the bromine acetaldehyde compressed ethylene glycol reaction to obtain 1 - (4 - (2,2-methoxyethoxy) - 2-hydroxy-phenyl) ethanone, then the ring, and aryl acyl chloride reaction, the rearranged under alkaline conditions to obtain multi-substituted aromatic diketone compound. When the R 1 (I-2) for the time, the method of this invention and R 1 (I-1) is basically the same as the. When the R 1 formula (I-3) time, the method of the invention is to to phloroglucinol as raw materials, by methylation of 1, 3, 5-trimethoxy, by reaction with acetyl chloride 1,1 ˊ - (2-hydroxy -4,6-dimethoxy -1,3-phenylene) b ethanone, then the aryl acyl chloride reaction, the rearranged under alkaline conditions to obtain multi-substituted aromatic diketone compound. Compound of the present invention, to HIV-1 integrase inhibiting effect. (by machine translation)