855936-17-3

Basic information

• Product Name: Ethanone,1-(2-amino-5-chloro-4-methylphenyl)-
• Synonyms: Ethanone,1-(2-amino-5-chloro-4-methylphenyl)-
• CAS NO: 855936-17-3
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.63
• Mol File: 855936-17-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 323.6°C at 760 mmHg
• Flash Point: 149.5°C
• Appearance: /
• Density: 1.212g/cm³
• Vapor Pressure: 0.000259mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: Ethanone,1-(2-amino-5-chloro-4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone,1-(2-amino-5-chloro-4-methylphenyl)-(855936-17-3)
• EPA Substance Registry System: Ethanone,1-(2-amino-5-chloro-4-methylphenyl)-(855936-17-3)

Safety Data

• Hazardous Substances Data: 855936-17-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H10ClNO/c1-5-3-9(11)7(6(2)12)4-8(5)10/h3-4H,11H2,1-2H3

Upstream product

• 7149-75-9 3-methyl-4-chloroaniline 
• 75-05-8 acetonitrile 

Downstream Products

• 937817-50-0 (2-acetyl-4-chloro-5-methylphenylamino)acetic acid ethyl ester 
• 937817-28-2 N-(2-acetyl-4-chloro-5-methylphenyl)glycine 

Relevant articles and documents

Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase

A series of potent anthranilic acid-based inhibitors of the hepatitis C NS5B polymerase has been identified. The inhibitors bind to a site on NS5B between the thumb and palm regions adjacent to the active site as determined by X-ray crystallography of the enzyme-inhibitor complex. Guided by both molecular modeling and traditional SAR, the enzyme activity of the initial hit was improved by approximately 100-fold, yielding a series of potent and selective NS5B inhibitors with IC50 values as low as 10 nM. These compounds were also inhibitors of the HCV replicon in cultured HUH7 cells.