856152-84-6

Basic information

• Product Name: 4-ethoxy-1-ethyl-5-methyl-2(1H)-pyrimidinone
• Synonyms: 4-ethoxy-1-ethyl-5-methyl-2(1H)-pyrimidinone
• CAS NO: 856152-84-6
• Molecular Weight: 182.222
• Mol File: 856152-84-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-ethoxy-1-ethyl-5-methyl-2(1H)-pyrimidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethoxy-1-ethyl-5-methyl-2(1H)-pyrimidinone(856152-84-6)
• EPA Substance Registry System: 4-ethoxy-1-ethyl-5-methyl-2(1H)-pyrimidinone(856152-84-6)

Safety Data

• Hazardous Substances Data: 856152-84-6(Hazardous Substances Data)

Upstream product

• 64-67-5 diethyl sulfate 
• 65-71-4 thymin 

Relevant articles and documents

HSAB-driven chemoselective N1-alkylation of pyrimidine bases and their 4-methoxy- or 4-acetylamino-derivatives

The lithium salts of the conjugated bases of 4-methoxy- and 4-acetylamino-2(1H)-pyrimidinones 1-3 undergo highly chemoselective N1-methylation or ethylation when treated with methyl- or ethylsulfate (hard electrophiles) in dry dioxane, while the use of DMF as solvent results in competitive O2-alkylation. Potassium salts of the same bases in DMF undergo prevalent O2-attack. Under the same conditions, a similar but less chemoselective behaviour is observed in alkylation of thymine and uracil, where some N3-attack occurs. This can be rationalised in terms of the HSAB principle.