85630-21-3

Basic information

• Product Name: N,N-diethyl-1-carbamoyloxybenzene-2-carboxaldehyde
• Synonyms: N,N-diethyl-1-carbamoyloxybenzene-2-carboxaldehyde
• CAS NO: 85630-21-3
• Molecular Weight: 221.256
• Mol File: 85630-21-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-1-carbamoyloxybenzene-2-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-1-carbamoyloxybenzene-2-carboxaldehyde(85630-21-3)
• EPA Substance Registry System: N,N-diethyl-1-carbamoyloxybenzene-2-carboxaldehyde(85630-21-3)

Safety Data

• Hazardous Substances Data: 85630-21-3(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 88-10-8 N,N-diethylcarbamyl chloride 
• 77253-32-8 N-ethyl-N-propylformamide 
• 108-95-2 phenol 
• 634-95-7 N,N-diethylurea 
• 617-84-5 N-formyldiethylamine 
• 65009-00-9 O-phenyl N,N-diethylcarbamate 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 731785-56-1 2-(N,N-diethyl-1-carbamoyloxyphenyl-2-)-1,3-dioxane 

Relevant articles and documents

Corrigendum to “Copper ferrite superparamagnetic nanoparticles as a heterogeneous catalyst for directed phenol/formamide coupling” [Tetrahedron Lett. 58 (2017) 3370–3373] (Tetrahedron Letters (2017) 58(34) (3370–3373), (S0040403917309048), (10.1016/j.tetl

The authors regret that some characterization images of the catalyst and some NMR data of the compounds in Table 2 were shown incorrectly in the Supplementary Data. The coupling reactions were therefore re-run using the reported procedure and isolation of

Synthesis method of medicine intermediate carbamate compounds

The invention provides a synthesis method of medicine intermediate carbamate compounds. Compounds disclosed as Formula (I) and compounds disclosed as Formula (II) react in an organic solvent in the presence of a catalyst and a ligand to obtain carbamate compounds. The method implements high-yield synthesis of carbamate compounds, and has favorable application prospects.

Copper-catalyzed cross dehydrogenative coupling of N,N-disubstituted formamides and phenols: A direct access to carbamates

An efficient copper-catalyzed protocol has been developed for the synthesis of carbamates from dialkylformamides and phenols possessing directing groups such as benzothiazole, quinoline and formyl at the ortho-position. In this chelation assisted approach, C-O bond formation takes place via a cross dehydrogenative coupling (CDC) between the formyl C-H of dialkylformamide and phenolic O-H in the presence of copper(II)acetate/aqueous tertbutyl hydroperoxide. Under identical reaction conditions, salicylic acid derivatives underwent amidation with the carboxylic group rather than formamidation of the phenolic OH. The use of a cheap and environmentally benign catalyst along with the tolerance of a wide range of functional groups makes this an easy, phosgene-free route to carbamates. carbamates; C-H activation; copper catalysis; cross dehyrogenative coupling