85684-64-6

Basic information

• Product Name: 2-(DIFLUOROMETHOXY)BENZYL BROMIDE
• Synonyms: 2-(DIFLUOROMETHOXY)BENZYL BROMIDE;O-DIFLUOROMETHOXYBENZYLBROMIDE;alpha-Bromo-2-difluoromethoxytoluene;à-bromo-2-difluoromethoxytoluene;2-(Difluoromethoxy)benzyl bromide 98%;2-(Difluoromethoxy)benzylbromide98%;1-(BroMoMethyl)-2-(difluoroMethoxy)benzene;1-(Bromomethyl)-2-(difluoromethoxy)benzene, 2-(Bromomethyl)phenyl difluoromethyl ether
• CAS NO: 85684-64-6
• Molecular Formula: C₈H₇BrF₂O
• Molecular Weight: 237.04
• Product Categories: Fluorine series
• Mol File: 85684-64-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 222°C
• Flash Point: 108°C
• Appearance: clear, colorless to pale yellow liquid
• Density: 1,555 g/cm3
• Vapor Pressure: 0.131mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility: Immiscible with water.
• Sensitive: Lachrymatory
• CAS DataBase Reference: 2-(DIFLUOROMETHOXY)BENZYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(DIFLUOROMETHOXY)BENZYL BROMIDE(85684-64-6)
• EPA Substance Registry System: 2-(DIFLUOROMETHOXY)BENZYL BROMIDE(85684-64-6)

Safety Data

• Hazard Codes: C
• Statements: 34-36/37/38-40
• Safety Statements: 24/25-26-36/37/39-45
• RIDADR: 2922
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 85684-64-6(Hazardous Substances Data)

Usage

Uses

2-(Difluoromethoxy)benzyl bromide is used as a building block in organic synthesis. It also serves as a coupling reagent and N-protecting reagent. Further, it is used as a gas chromatography derivatizing agent.

InChI:InChI=1/C8H7BrF2O/c9-5-6-3-1-2-4-7(6)12-8(10)11/h1-4,8H,5H2

Upstream product

• 42173-52-4 difluoromethyl 2-methylphenyl ether 
• 72768-94-6 2-(difluoromethoxy)benzyl alcohol 
• 71653-64-0 o-difluoromethoxybenzaldehyde 

Relevant articles and documents

Synthesis of Phenanthridines through Palladium-Catalyzed Cascade Reaction of 2-Halo-N-Ms-arylamines with Benzyl Halides/Sulfonates

An efficient palladium-catalyzed nucleophilic substitution/C–H activation/aromatization cascade reaction between readily available 2-halo-N-Ms-arylamines (Ms = methanesulfonyl) and benzyl halides/sulfonates has been described. A wide variety of phenanthridines were synthesized in a one-pot fashion in moderate to high yields (37–86 %). Notably, this method provides a straightforward, facile approach for the synthesis of phenanthridines. The practicality was further substantiated by successfully carrying out a gram-scale preparation.