85695-26-7

Basic information

• Product Name: Silane, trimethyl[4-[2,2,2-trichloro-1-[(trimethylsilyl)oxy]ethyl]phenoxy]-
• CAS NO: 85695-26-7
• Molecular Formula: C14H23Cl3O2Si2
• Molecular Weight: 385.865
• Mol File: 85695-26-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Silane, trimethyl[4-[2,2,2-trichloro-1-[(trimethylsilyl)oxy]ethyl]phenoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, trimethyl[4-[2,2,2-trichloro-1-[(trimethylsilyl)oxy]ethyl]phenoxy]-(85695-26-7)
• EPA Substance Registry System: Silane, trimethyl[4-[2,2,2-trichloro-1-[(trimethylsilyl)oxy]ethyl]phenoxy]-(85695-26-7)

Safety Data

• Hazardous Substances Data: 85695-26-7(Hazardous Substances Data)

Upstream product

• 5936-98-1 trichloromethyltrimethylsilane 
• 1012-12-0 4-(trimethylsiloxy)benzaldehyde 
• 25436-07-1 trimethylsilyl trichloroacetate 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 50597-25-6 2,2,2-trichloro-1-(4-hydroxyphenyl)ethanol 

Relevant articles and documents

Trichloromethyltrimethylsilane, sodium formate, and dimethylformamide: A mild, efficient, and general method for the preparation of trimethylsilyl- protected 2,2,2-trichloromethylcarbinols from aldehydes and ketones

(Chemical Equation Presented) New conditions for the preparation of trimethylsilyl-protected 2,2,2-trichloromethylcarbinols 2 from aldehydes and ketones are reported. Compounds 2, which are important intermediates in organic synthesis, were obtained in excellent yields by use of a combination of trichloromethyltrimethylsilane (TMSCCI3), and a catalytic amount of sodium formate (HCOONa) in dimethylformamide (DMF). Substrates bearing highly sensitive protecting groups have been successfully subjected to our conditions. We also describe a one-pot procedure that gives direct access to 2,2,2-trichloromethylcarbinols 3. This methodology avoids the use of strong bases usually required for the synthesis of 3 (Wyvratt et al. J. Org. Chem. 1987, 52, 944; Aggarwal and Mereu, J. Org. Chem. 2000, 65, 7211).