857226-16-5

Basic information

• Product Name: 1-(2-hydroxy-4,5-dimethoxyphenyl)propan-1-one
• Synonyms: 1-(2-hydroxy-4,5-dimethoxyphenyl)propan-1-one
• CAS NO: 857226-16-5
• Molecular Weight: 210.23
• Mol File: 857226-16-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(2-hydroxy-4,5-dimethoxyphenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-hydroxy-4,5-dimethoxyphenyl)propan-1-one(857226-16-5)
• EPA Substance Registry System: 1-(2-hydroxy-4,5-dimethoxyphenyl)propan-1-one(857226-16-5)

Safety Data

• Hazardous Substances Data: 857226-16-5(Hazardous Substances Data)

Upstream product

• 2033-89-8 3,4-dimethoxyphenol 
• 79-03-8 propionyl chloride 
• 123-62-6 propionic acid anhydride 
• 613-03-6 1,2,4-triacetoxybenzene 
• 107-12-0 propiononitrile 
• 135-77-3 1,2,4-trimethoxy-benzene 

Downstream Products

• 856809-88-6 2-(4,5-dimethoxy-2-propionyl-phenoxy)-propionic acid ethyl ester 
• 855220-98-3 3-ethyl-5,6-dimethoxy-2-methyl-benzofuran 
• 856809-89-7 2-(4,5-dimethoxy-2-propionyl-phenoxy)-propionic acid 
• 1298120-44-1 N-((2S,3R)-4-amino-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-6,7-dimethoxy-3-methyl-4-oxo-4H-chromene-2-carboxamide 
• 1298120-18-9 (S)-N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-6,7-dimethoxy-3-methyl-4-oxo-4H-chromene-2-carboxamide 
• 1298120-20-3 (S)-N-(4-benzylamino-3,4-dioxo-1-phenylbutan-2-yl)-6,7-dimethoxy-3-methyl-4-oxo-4H-chromene-2-carboxamide 
• 1298120-21-4 (S)-6,7-dimethoxy-N-(4-(4-methoxyphenethyl amino)-3,4-dioxo-1-phenylbutan-2-yl)-3-methyl-4-oxo-4H-chromene-2-carboxamide 
• 1298120-36-1 (S)-N-(4-benzylamino-3,4-dioxo-1-phenylbutan-2-yl)-6,7-dihydroxy-3-methyl-4-oxo-4H-chromene-2-carboxamide 
• 1298120-37-2 (S)-6,7-dihydroxy-N-(4-(4-methoxyphenethylamino)-3,4-dioxo-1-phenylbutan-2-yl)-3-methyl-4-oxo-4H-chromene-2-carboxamide 
• 6906-69-0 4,5-dimethoxy-2-propylphenol 

Relevant articles and documents

Synthesis and biological evaluation of novel chromonyl enaminones as α-glucosidase inhibitors

Series of novel chromonyl enaminones 1a–e and 2a–e and 3-alkylated chromones 3a–e were synthesized and evaluated in vitro as α-glucosidase inhibitors as well as antioxidant and antifungal agents. Antifungal activity was tested on strains of Candida albicans. Compounds 2a and 2d–e showed good inhibition of the α-glucosidase enzyme (IC50 = 5.5, 0.9, and 1.5 mM, respectively), their effect being better than that of 1a–e, 3a–e, and acarbose (the standard, IC50 = 7.73 ± 0.9 mM). The structure–activity relationship suggests that the phenyl group at the C-3 position of the chromone ring system and the 4-chlorophenyl group at the enaminone moiety (derivatives 2) increased the inhibition of α-glucosidase. Compounds 2a–e exhibited a slight antioxidant effect, and compounds 3a–e a moderate antifungal activity against C. albicans (IC50 70.5–83.1 μg/mL). Docking studies revealed that compounds 2 interact with the α-glucosidase residues of the binding pocket. Therefore, these chromone derivatives may be considered as potential α-glucosidase inhibitors, as well as antifungal agents against some Candida strains of yeast.

Synthesis of chromone carboxamide derivatives with antioxidative and calpain inhibitory properties

The overactivation of μ-calpain can cause serious cell damage in several diseases. Furthermore, cell death in a number of neurodegenerative disorders is linked to the overproduction of reactive oxygen species. Therefore, antioxidants and μ-calpain inhibit