85760-88-9 Usage
Description
(S)-N,N-diethyl-5-oxopyrrolidine-2-carboxamide, also known as DEPC or Diethylpyrrolidonecarboxamide, is a chemical compound with the molecular formula C10H18N2O2. It belongs to the class of pyrrolidine carboxamides and is an organic compound. (S)-N,N-diethyl-5-oxopyrrolidine-2-carboxamide has been studied for its potential therapeutic applications and has shown anticonvulsant and neuroprotective properties in animal models. Furthermore, it has been investigated for its use as a chiral building block in organic chemistry due to its asymmetric carbon center.
Uses
Used in Pharmaceutical Synthesis:
(S)-N,N-diethyl-5-oxopyrrolidine-2-carboxamide is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and properties make it a valuable component in the development of new drugs.
Used in Therapeutic Applications:
In the field of medicine, (S)-N,N-diethyl-5-oxopyrrolidine-2-carboxamide is used as a potential therapeutic agent for its demonstrated anticonvulsant and neuroprotective properties. It has shown promise in animal models, and further research is needed to explore its full potential in treating various conditions.
Used in Organic Chemistry:
(S)-N,N-diethyl-5-oxopyrrolidine-2-carboxamide is also used as a chiral building block in organic chemistry. Its asymmetric carbon center makes it a valuable compound for the development of enantiomerically pure molecules, which are essential in various chemical reactions and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 85760-88-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,7,6 and 0 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 85760-88:
(7*8)+(6*5)+(5*7)+(4*6)+(3*0)+(2*8)+(1*8)=169
169 % 10 = 9
So 85760-88-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H16N2O2/c1-3-11(4-2)9(13)7-5-6-8(12)10-7/h7H,3-6H2,1-2H3,(H,10,12)
85760-88-9Relevant articles and documents
Synthesis and bioactivities evaluation of L-pyroglutamic acid analogues from natural product lead
Gang, Fang-li,Zhu, Feng,Li, Xiao-ting,Wei, Jie-lu,Wu, Wen-jun,Zhang, Ji-wen
, p. 4644 - 4649 (2018/08/21)
A series of L-pyroglutamic acid analogues from natural product lead were designed and synthesized, as well as their antifungal activities against Phytophthora infestans, neuritogenic activities, antibacterial activities and anti-inflammatory activities are described. The bioassays and SAR study showed that the majority of L-pyroglutamic acid esters have a significant antifungal activity against P. infestans, especially 2d and 2j demonstrated the best activities with EC50 values of 1.44 and 1.21 μg mL?1, which were about seven times that of commercial azoxystrobin (7.85 μg mL?1). Moreover, compounds 2e, 2g and 4d displayed anti-inflammatory activity against LPS-induced NO production in BV-2 microglial cells; neuritogenic activity in NGF-induced PC-12 cells is the same activity. This study demonstrates that compounds 2d and 2j are potential drugs to control P. infestans.
Studies on pyrrolidones. An improved synthesis of pyroglutamoyl chloride
Rigo,El Ghammarti,Gautret,Couturier
, p. 2597 - 2607 (2007/10/02)
The reaction of trimethylsilyl pyroglutamate with oxalyl chloride at room temperature easily yields pyroglutamoyl chloride. This unstable compound, obtained with difficulty by other methods, is suitable for the preparation of pyroglutamic esters and amides.
