85798-96-5 Usage
Description
6-Hydroxyisocompactin is a metabolite of Pravastatin (P702000), which is a competitive inhibitor of HMG-CoA reductase. It is an off-white solid with unique chemical properties.
Uses
Used in Pharmaceutical Industry:
6-Hydroxyisocompactin is used as an active pharmaceutical ingredient for the development of cholesterol-lowering drugs. It functions as a competitive inhibitor of HMG-CoA reductase, an enzyme involved in cholesterol synthesis, thereby helping to reduce cholesterol levels in the body.
Used in Research Applications:
6-Hydroxyisocompactin is used as a research compound for studying the mechanisms of cholesterol synthesis and the effects of HMG-CoA reductase inhibition on various biological processes. It aids in understanding the role of statins in managing hypercholesterolemia and cardiovascular diseases.
Used in Drug Metabolism Studies:
6-Hydroxyisocompactin is used as a metabolite in drug metabolism studies, providing insights into the biotransformation of Pravastatin and its impact on the pharmacokinetics and pharmacodynamics of the drug. This information is crucial for optimizing drug dosages and minimizing side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 85798-96-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,7,9 and 8 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 85798-96:
(7*8)+(6*5)+(5*7)+(4*9)+(3*8)+(2*9)+(1*6)=205
205 % 10 = 5
So 85798-96-5 is a valid CAS Registry Number.
InChI:InChI=1/C23H34O6/c1-4-13(2)23(27)29-20-7-5-6-15-10-19(25)14(3)18(22(15)20)9-8-17-11-16(24)12-21(26)28-17/h5-6,10,13-14,16-20,22,24-25H,4,7-9,11-12H2,1-3H3
85798-96-5Relevant articles and documents
Capillary electrophoresis determination of pravastatin and separation of its degradation products
Nigovic, Biljana,Vegar, Ivana
experimental part, p. 615 - 622 (2009/12/03)
A capillary zone electrophoresis method for pravastatin determination was developed and validated. Rapid migration of negatively charged pravastatin molecule was obtained in alkaline buffer by the application of electric field of 30 kV. Influence of the pH value and ionic strength of running buffer, applied voltage and capillary temperature on mobility and sensitivity was evaluated. Detection wavelength was set to 237 nm. The method was applied to the determination of the drug in pharmaceutical dosage form. Pravastatin is a δ-hydroxy acid, which is prone to lactonize and epimerize in a pH-dependent manner. Micellar electrokinetic chromatographic approach was chosen to develop a method able to separate pravastatin and its degradation products in acidic media. The proposed method allows baseline separation of hydroxy acid and neutral lactone forms of the drug that appear as interconversion products depending on the pH value.
