858232-97-0 Usage
Description
(7-methyl-1H-indol-3-yl)acetonitrile is a chemical compound with the molecular formula C11H10N2, derived from the heterocyclic compound indole, which is commonly found in certain plants and utilized in the synthesis of various pharmaceuticals and organic compounds. (7-methyl-1H-indol-3-yl)acetonitrile features a nitrile functional group, making it a versatile building block for constructing more complex molecules in organic synthesis. The presence of the indole ring and the acetonitrile group endows it with potential applications in medicinal chemistry and other areas within organic chemistry. The 7-methyl substitution on the indole ring may also confer specific properties or reactivity to this compound.
Uses
Used in Pharmaceutical Synthesis:
(7-methyl-1H-indol-3-yl)acetonitrile is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be a versatile building block in creating complex molecules.
Used in Organic Chemistry:
(7-methyl-1H-indol-3-yl)acetonitrile is used as a reagent in organic chemistry due to its nitrile functional group, which allows for further reactions and the formation of a wide range of organic compounds.
Used in Medicinal Chemistry:
(7-methyl-1H-indol-3-yl)acetonitrile is used as a starting material for the development of new drugs in medicinal chemistry, taking advantage of its indole ring and potential for specific reactivity due to the 7-methyl substitution.
Used in Chemical Research:
(7-methyl-1H-indol-3-yl)acetonitrile is used as a research compound to study the properties and reactivity of indole derivatives and nitrile-containing compounds, contributing to the advancement of chemical knowledge and potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 858232-97-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,8,2,3 and 2 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 858232-97:
(8*8)+(7*5)+(6*8)+(5*2)+(4*3)+(3*2)+(2*9)+(1*7)=200
200 % 10 = 0
So 858232-97-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H10N2/c1-8-3-2-4-10-9(5-6-12)7-13-11(8)10/h2-4,7,13H,5H2,1H3
858232-97-0Relevant articles and documents
Tryptamine Synthesis by Iron Porphyrin Catalyzed C?H Functionalization of Indoles with Diazoacetonitrile
Hock, Katharina J.,Knorrscheidt, Anja,Hommelsheim, Renè,Ho, Junming,Weissenborn, Martin J.,Koenigs, Rene M.
supporting information, p. 3630 - 3634 (2019/02/13)
The functionalization of C?H bonds with non-precious metal catalysts is an important research area for the development of efficient and sustainable processes. Herein, we describe the development of iron porphyrin catalyzed reactions of diazoacetonitrile with N-heterocycles yielding important precursors of tryptamines, along with experimental mechanistic studies and proof-of-concept studies of an enzymatic process with YfeX enzyme. By using readily available FeTPPCl, we achieved the highly efficient C?H functionalization of indole and indazole heterocycles. These transformations feature mild reaction conditions, excellent yields with broad functional group tolerance, can be conducted on gram scale, and thus provide a unique streamlined access to tryptamines.
