85862-85-7

Basic information

• Product Name: 4-azido-2-chloro-1-fluorobenzene
• Synonyms: 4-azido-2-chloro-1-fluorobenzene
• CAS NO: 85862-85-7
• Molecular Weight: 171.561
• Mol File: 85862-85-7.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 4-azido-2-chloro-1-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-azido-2-chloro-1-fluorobenzene(85862-85-7)
• EPA Substance Registry System: 4-azido-2-chloro-1-fluorobenzene(85862-85-7)

Safety Data

• Hazardous Substances Data: 85862-85-7(Hazardous Substances Data)

Upstream product

• 144432-85-9 3-chloro-4-fluorophenylboronic acid 
• 367-21-5 3-chloro-4-fluorophenylamine 

Downstream Products

• 1187324-93-1 ethyl 1-(3-chloro-4-fluorophenyl)-4-methyl-1H-1,2,3-triazole-5-carboxylate 
• 1187324-91-9 ethyl 1-(3-chloro-4-fluorophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylate 
• 1446211-83-1 2-((1-(3-chloro-4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methylthio)-5-phenyl-1,3,4-oxadiazole 

Relevant articles and documents

Synthesis and antitumor activity of 1-substituted 1,2,3-triazole-mollugin derivatives

A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding O-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds 14 and 17 exhibited significant cytotoxicity of all five cancer cell lines.

Synthesis of New Thieno[2,3-d]pyrimidines Containing a 1,2,3-Triazole Ring and Their Therapeutic Response in NCI-60 Cell Line Panel

Abstract: A series of new tetrahydro[1]benzothieno[2,3-d]pyrimidines containing a 1,2,3-triazole fragment linkedthrough an oxymethylene spacer have been synthesized by click reaction of4-(prop-2-yn-1-yloxy)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidines with various aryl and alkyl azides inthe presence of copper sulfate and sodium ascorbate as a catalyst. Thestructures of the synthesized compounds were characterized by variousspectroscopic techniques (1H and13C NMR, FT-IR, and mass spectrometry), and theirin vitro anticancer activity against NCI-60 human tumor cell lines wasevaluated. Among the compounds tested, N-(pyridine-3-yl)-acetamide derivative exhibited significantactivity against several cancer cell lines, including SF-539 (CNS cancer),HCT-116 (colon cancer), OVCAR-8 (ovarian cancer), PC-3 (prostate cancer), andCCRF-CEM (leukemia).

Ultrasonic-Assisted Synthesis of Pyrazolo[3,4-d]pyrimidin-4-ol Tethered with 1,2,3-Triazoles and Their Anticancer Activity

Abstract: In the presents work synthesis and characterization of new heterocyclic derivatives containing pyrazolo[3,4-d]pyrimidine linkage with 1,4-disubstituted-1,2,3-triazoles via methylene-oxy group. The selected synthesized compounds were tested for their in-vitro anticancer activity against various cancer cell lines. Synthesis of compounds was done under ultrasonic-assisted Huisgen 1,3-dipolar cycloaddition reaction with good yields. Some of the newly synthesized compounds demonstrated good to moderate anticancer activity, most of compounds shows activity against renal cancer cell lines.