85916-47-8

Basic information

• Product Name: KATACALCIN
• Synonyms: KATACALCIN;KATACALCIN (HUMAN);C-PROCALCITONIN;C-PROCALCITONIN (HUMAN);CALCITONIN C-TERMINAL FLANKING PEPTIDE (HUMAN);DMSSDLERDHRPHVSMPQNAN;H-ASP-MET-SER-SER-ASP-LEU-GLU-ARG-ASP-HIS-ARG-PRO-HIS-VAL-SER-MET-PRO-GLN-ASN-ALA-ASN-OH;ASP-MET-SER-SER-ASP-LEU-GLU-ARG-ASP-HIS-ARG-PRO-HIS-VAL-SER-MET-PRO-GLN-ASN-ALA-ASN
• CAS NO: 85916-47-8
• Molecular Formula: C97H154N34O36S2
• Molecular Weight: 2436.6
• Product Categories: Peptide
• Mol File: 85916-47-8.mol
• Article Data: 0

Chemical Properties

• Appearance: White powder
• Density: 1.62±0.1 g/cm3(Predicted)
• Storage Temp.: -15°C
• CAS DataBase Reference: KATACALCIN(CAS DataBase Reference)
• NIST Chemistry Reference: KATACALCIN(85916-47-8)
• EPA Substance Registry System: KATACALCIN(85916-47-8)

Safety Data

• Hazardous Substances Data: 85916-47-8(Hazardous Substances Data)

Usage

Description

Katacalcin, also known as calcitonin gene-related peptide (CGRP), is a 32-amino acid peptide hormone that is produced and secreted by the thyroid C cells. It is involved in the regulation of calcium metabolism and plays a crucial role in maintaining calcium homeostasis in the body.

Uses

Used in Medical Diagnostics:
Katacalcin is used as a biomarker for the detection of medullary thyroid carcinoma, a rare type of thyroid cancer that arises from the parafollicular C cells. Elevated levels of katacalcin in the blood can indicate the presence of this cancer, aiding in early diagnosis and treatment.
Used in Calcium Metabolism Regulation:
Katacalcin is used as a hormone to regulate calcium metabolism in the body. It works by inhibiting the release of calcium from bones, promoting calcium excretion in the kidneys, and reducing the absorption of calcium in the intestines. This helps to maintain optimal calcium levels in the blood and prevent conditions such as hypercalcemia.
Used in Osteoporosis Treatment:
Katacalcin has potential therapeutic applications in the treatment of osteoporosis, a condition characterized by low bone mass and increased risk of fractures. By inhibiting bone resorption and promoting bone formation, katacalcin can help to improve bone density and strength, reducing the risk of fractures in osteoporotic patients.
Used in Pain Management:
Katacalcin has been found to have analgesic properties and can be used in pain management, particularly for conditions such as migraines and cluster headaches. It is believed to exert its pain-relieving effects by modulating the activity of the trigeminal nerve, which is involved in the transmission of pain signals in the head.
Used in Neuroprotection:
Katacalcin has been shown to have neuroprotective effects and can be used in the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's. It is thought to protect neurons from damage and degeneration by reducing inflammation, oxidative stress, and apoptosis, thereby preserving cognitive function and motor control.

InChI:InChI=1/C97H154N34O36S2/c1-43(2)29-55(119-83(154)60(36-72(143)144)123-86(157)62(39-132)127-87(158)63(40-133)126-79(150)52(21-27-168-7)113-75(146)48(98)32-70(139)140)81(152)115-51(18-20-69(137)138)77(148)114-49(13-9-23-108-96(102)103)76(147)122-59(35-71(141)142)84(155)120-56(30-46-37-106-41-110-46)82(153)117-53(14-10-24-109-97(104)105)93(163)130-25-12-16-65(130)89(160)124-57(31-47-38-107-42-111-47)85(156)128-73(44(3)4)90(161)129-92(167-6)91(162)118-54(22-28-169-8)94(164)131-26-11-15-64(131)88(159)116-50(17-19-66(99)134)78(149)121-58(33-67(100)135)80(151)112-45(5)74(145)125-61(95(165)166)34-68(101)136/h37-38,41-45,48-65,73,92,132-133H,9-36,39-40,98H2,1-8H3,(H2,99,134)(H2,100,135)(H2,101,136)(H,106,110)(H,107,111)(H,112,151)(H,113,146)(H,114,148)(H,115,152)(H,116,159)(H,117,153)(H,118,162)(H,119,154)(H,120,155)(H,121,149)(H,122,147)(H,123,157)(H,124,160)(H,125,145)(H,126,150)(H,127,158)(H,128,156)(H,129,161)(H,137,138)(H,139,140)(H,141,142)(H,143,144)(H,165,166)(H4,102,103,108)(H4,104,105,109)/t45-,48-,49?,50-,5