85943-75-5

Basic information

• Product Name: Benzaldehyde, 5-(1,1-dimethylethyl)-2-hydroxy-3-nitro-
• CAS NO: 85943-75-5
• Molecular Formula: C11H13NO4
• Molecular Weight: 223.229
• Mol File: 85943-75-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 5-(1,1-dimethylethyl)-2-hydroxy-3-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 5-(1,1-dimethylethyl)-2-hydroxy-3-nitro-(85943-75-5)
• EPA Substance Registry System: Benzaldehyde, 5-(1,1-dimethylethyl)-2-hydroxy-3-nitro-(85943-75-5)

Safety Data

• Hazardous Substances Data: 85943-75-5(Hazardous Substances Data)

Upstream product

• 2725-53-3 2-hydroxy-5-t-butylbenzaldehyde 

Downstream Products

• 1262020-39-2 (Z)-2-benzylidene-7-nitro-5-tert-butyl-2,3-dihydrobenzofuran-3-ol 
• 1262020-31-4 C₁₉H₁₉NO₄ 
• 85943-76-6 5-tert-butyl-2-hydroxyl-3-nitro-benzonitrile 
• 100373-31-7 5-tert-butyl-2-hydroxy-3-nitro-cis-cinnamic acid 
• 344907-68-2 (R,R)-N,N'-bis(3-nitro-5-tert-butylsalicylidene)-1,2-cyclohexanediamine 
• 1269761-60-5 4-tert-butyl-2-(1,3-diphenylimidazolidin-2-yl)-6-nitrophenol 
• 99758-66-4 5-(tert-butyl)-2-methoxy-3-nitrobenzaldehyde 
• 1269761-67-2 C₃₆H₄₇N₃O₄ 
• 1269761-68-3 C₄₈H₆₂N₄O₅ 
• 1269761-70-7 C₇₂H₉₂N₆O₇ 
• 100393-96-2 6-tert-butyl-8-nitro-coumarin 
• 100373-31-7 5-tert-butyl-2-hydroxy-3-nitro-trans-cinnamic acid 

Relevant articles and documents

Salicylaldehyde Hydrazones: Buttressing of Outer-Sphere Hydrogen-Bonding and Copper Extraction Properties

Salicylaldehyde hydrazones are weaker copper extractants than their oxime derivatives, which are used in hydrometallurgical processes to recover ～20% of the world's copper. Their strength, based on the extraction equilibrium constant Ke, can be increased by nearly three orders of magnitude by incorporating electron-withdrawing or hydrogen-bond acceptor groups (X) ortho to the phenolic OH group of the salicylaldehyde unit. Density functional theory calculations suggest that the effects of the 3-X substituents arise from a combination of their influence on the acidity of the phenol in the pH-dependent equilibrium, Cu2++2Lorg→[Cu(L-H)2]org+2H+, and on their ability to 'buttress' interligand hydrogen bonding by interacting with the hydrazone N-H donor group. X-ray crystal structure determination and computed structures indicate that in both the solid state and the gas phase, coordinated hydrazone groups are less planar than coordinated oximes and this has an adverse effect on intramolecular hydrogen-bond formation to the neighbouring phenolate oxygen atoms.

7-(Piperazine-1-Ymethyl)-1H-Indole-2-Carboxylic Acid (Phenyl)-Amide Derivatives and Allied Compounds as P38 Map Kinase Inhibitors for the Treatment of Respiratory Diseases

The present invention provides compounds according to general formula (I) which are proposed for the treatment of respiratory complaints, particularly asthma and COPD.

NEW CHEMICAL COMPOUNDS

The present invention encompasses compounds of general formula (1), wherein the groups R1 to R3 and L are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for