859498-34-3 Usage
Description
(2,4R,5S)-N-tert-butoxycarbonyl-2-(4'-methoxy)phenyl-4-phenyl-1,3-oxazolidine-5-formic acid is a complex organic compound featuring a 1,3-oxazolidine ring with a carboxylic acid group, a tert-butoxycarbonyl group, and phenyl and methoxyphenyl substituents. (2,4R,5S)-N-tert-butoxycarbonyl-2-(4'-methoxy)phenyl-4-phenyl-1,3-oxazolidine-5-formic acid is characterized by its stereochemistry, with the 2, 4R, and 5S configurations, which are crucial for its reactivity and potential applications.
Uses
Used in Pharmaceutical Synthesis:
(2,4R,5S)-N-tert-butoxycarbonyl-2-(4'-methoxy)phenyl-4-phenyl-1,3-oxazolidine-5-formic acid is used as a key intermediate in the synthesis of complex pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block for the development of new drugs with specific therapeutic properties.
Used in the Preparation of Docetaxel:
Specifically, (2,4R,5S)-N-tert-butoxycarbonyl-2-(4'-methoxy)phenyl-4-phenyl-1,3-oxazolidine-5-formic acid is a useful reagent for the preparation of Docetaxel (D494420) and its isomers. Docetaxel is a widely used chemotherapy drug for the treatment of various types of cancer, including breast, lung, and prostate cancer. (2,4R,5S)-N-tert-butoxycarbonyl-2-(4'-methoxy)phenyl-4-phenyl-1,3-oxazolidine-5-formic acid's role in the synthesis process is crucial for the production of this important medication.
Check Digit Verification of cas no
The CAS Registry Mumber 859498-34-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,9,4,9 and 8 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 859498-34:
(8*8)+(7*5)+(6*9)+(5*4)+(4*9)+(3*8)+(2*3)+(1*4)=243
243 % 10 = 3
So 859498-34-3 is a valid CAS Registry Number.
859498-34-3Relevant articles and documents
A novel method to synthesize docetaxel and its isomer with high yields
Qi, Chuan-Min,Wang, Yun-Feng,Yang, Ling-Chun
, p. 679 - 684 (2007/10/03)
Side chains of docetaxel and its isomer were obtained through Staudinger cycloaddition and catalytic hydrogenation of chlorophenyl intermediates, using chlorobenzaldehyde as starting material. Syntheses of three novel chiral azetidinone derivatives through the Staudinger cycloaddition reaction of chlorophenyl chiral amine Schiff base with different substituted positions were described and their ring-opening reaction under the catalysis of Pd/MgCO 3 or Pd/C to afford side chains of docetaxel and its isomer in high yields was investigated. Finally, docetaxel and its isomer were obtained. Single crystal of (3S,4R)-3-hydroxy-N-[(S)(1-phenyl)ethyl]-4 -(2′-chlorophenyl) -2-azetidinone (4c) was obtained, the configuration of which was determined by X-ray diffraction. Because of the mild cyclization reaction condition and convenient asymmetric resolution operation when p-chlorobenzaldehyde was employed instead of benzaldehyde, the yield of cyclization and hydrogenation increased dramatically and the total yield of docetaxel was higher than the result in literature. When o-chlorobenzaldehyde was employed instead of benzaldehyde an isomer of docetaxel was obtained by the same way.
