85955-59-5 Usage
Description
(R) Lisinopril, also known as the R,S,S-isomer of (S)-Lisinopril (L469018), is an orally active angiotensin-converting enzyme (ACE) inhibitor. It is one of the isomers of Lisinopril, a medication used to treat hypertension, heart failure, and other cardiovascular conditions.
Used in Pharmaceutical Industry:
(R) Lisinopril is used as an ACE inhibitor for the treatment of hypertension, heart failure, and other cardiovascular conditions. It works by blocking the action of angiotensin-converting enzyme, which helps to relax blood vessels and reduce blood pressure. This can help to improve blood flow and decrease the workload on the heart, making it a valuable treatment option for various cardiovascular conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 85955-59-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,9,5 and 5 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 85955-59:
(7*8)+(6*5)+(5*9)+(4*5)+(3*5)+(2*5)+(1*9)=185
185 % 10 = 5
So 85955-59-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H31N3O5/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29)/t16-,17+,18-/m0/s1
85955-59-5Relevant articles and documents
Process for separating the diastereomers of RSS-snd SSS-N- a [1-carboxy -3-Phenylpropyl] lysylproline
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Page/Page column 2, (2011/04/19)
A process for separating the diastereomers of RSS— and SSS—N-α[1-carboxy-3-phenylpropyl]lysylproline is described. Previous chromatographic processes for separating the diastereomers of this peptide active substance, such as for example adsorption chromatography, exhibited disadvantages with regard to the solvents used and throughput. These disadvantages do not occur if basic ion exchangers are used in the chromatographic separation of the diastereomers. In particular, purely aqueous solutions may be used as the eluent.
Synthesis of N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline (lisinopril).
Wu,Douglas,Ondeyka,Payne,Ikeler,Joshua,Patchett
, p. 352 - 354 (2007/10/02)
The synthesis and some of the spectral properties of N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline (lisinopril, MK-521) are described. This compound inhibits angiotensin-converting enzyme with an IC50 of 1.2 X 10(-9) M.
