85979-85-7Relevant articles and documents
Metallic reductant-free synthesis of α-substituted propionic acid derivatives through hydrocarboxylation of alkenes with a formate salt
Takaya, Jun,Miyama, Ko,Zhu, Chuan,Iwasawa, Nobuharu
supporting information, p. 3982 - 3985 (2017/04/11)
A PGeP-pincer palladium-catalyzed hydrocarboxylation of styrenes to obtain pharmaceutically important α-arylpropionic acid derivatives was achieved using a formate salt as both a reductant and a CO2 source. The reaction was also applicable to vinylsulfone and acrylates. Isotope labeling experiments demonstrated that a CO2-recycling mechanism is operative through generation and reaction of a benzylpalladium complex as a carbon nucleophile. This protocol has realized a mild and atom economical CO2-fixation reaction without the necessity of using strong metallic reductants.
Organic Syntheses without Solvent: Preparation of Sulfones and Dithioacetals
Bram, Georges,Loupy, Andre,Roux-Schmitt, Marie Claude,Sansoulet, Jean,Strzalko, Tekla,Seyden-Penne, Jacqueline
, p. 56 - 59 (2007/10/02)
Sulfones are prepared by alkylation of sulfinate salts under solid-liquid phase-transfer catalysis without solvent; dithioacetals are obtained by heterogeneous uncatalyzed reactions of potassium arenethiolates and gem-dihaloalkanes.In both cases, the yields are high and the reaction conditions are mild.Some limitations are given.
