859850-88-7

Basic information

• Product Name: 3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE
• Synonyms: 3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE;3-[(4-Methylpiperazin-1-yl)methyl]benzaldehyde 95%
• CAS NO: 859850-88-7
• Molecular Formula: C13H18N2O
• Molecular Weight: 218.29
• Mol File: 859850-88-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 333°C at 760 mmHg
• Flash Point: 137.3°C
• Appearance: /
• Density: 1.099g/cm³
• Vapor Pressure: 0.00014mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: 3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE(859850-88-7)
• EPA Substance Registry System: 3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE(859850-88-7)

Safety Data

• Hazardous Substances Data: 859850-88-7(Hazardous Substances Data)

Usage

General Description

3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE is a synthetic compound that falls into the chemical category of benzaldehydes. Its molecular formula is C12H18N2O and its molecular weight is 206.29 g/mol. 3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZALDEHYDE contains a benzaldehyde group, characterized by a benzene ring and a formyl group, attached to a 4-Methylpiperazin-1-yl-Methyl group. It is often used in organic synthesis, typically as a precursor or intermediary, especially in the pharmaceutical industry. Like many chemicals, its safety and handling procedures should be clearly understood and it should be stored properly to prevent any hazards. The detailed properties, such as its melting point, boiling point, solubility, and other chemical characteristics, would depend on specific exploration under controlled conditions.

InChI:InChI=1/C13H18N2O/c1-14-5-7-15(8-6-14)10-12-3-2-4-13(9-12)11-16/h2-4,9,11H,5-8,10H2,1H3

Upstream product

• 622381-66-2 [3-[(4-methylpiperazin-1-yl)methyl]phenyl]methanol 
• 52178-50-4 Methyl 3-formylbenzoate 
• 658689-29-3 methyl 3-[(4-methyl piperazine-1-yl)-methyl]benzoate 
• 109-01-3 1-methyl-piperazine 

Relevant articles and documents

Synthesis and in Vitro Anticancer Activity of the First Class of Dual Inhibitors of REV-ERBβ and Autophagy

Autophagy inhibition is emerging as a promising anticancer strategy. We recently reported that the circadian nuclear receptor REV-ERBβ plays an unexpected role in sustaining cancer cell survival when the autophagy flux is compromised. We also identified 4-[[[1-(2-fluorophenyl)cyclopentyl]amino]methyl]-2-[(4-methylpiperazin-1-yl)methyl]phenol, 1 (ARN5187), as a novel dual inhibitor of REV-ERBβ and autophagy. 1 had improved cytotoxicity against BT-474 breast cancer cells compared to chloroquine, a clinically relevant autophagy inhibitor. Here, we present the results of structure-activity studies, based around 1, that disclose the first class of dual inhibitors of REV-ERBβ and autophagy. This study led to identification of 18 and 28, which were more effective REV-ERBβ antagonists than 1 and were more cytotoxic to BT-474. The combination of optimal chemical and structural moieties of these analogs generated 30, which elicited 15-fold greater REV-ERBβ inhibitory and cytotoxic activities compared to 1. Furthermore, 30 induced death in a panel of tumor cell lines at doses 5-50 times lower than an equitoxic amount of chloroquine but did not affect the viability of normal mammary epithelial cells.