859966-28-2Relevant articles and documents
C5-Disubstituted Meldrum's Acid Derivatives as Platform for the Organocatalytic Synthesis of C3-Alkylated Dihydrocoumarins
Martzel, Thomas,Annibaletto, Julien,Levacher, Vincent,Brière, Jean-Fran?ois,Oudeyer, Sylvain
supporting information, p. 995 - 1000 (2019/01/30)
C5-disubstituted Meldrum's acid precursors were shown to be a useful platform for the synthesis of an array of 3-alkylated dihydrocoumarins with up to 93:7 er, thanks to an enantioselective domino cyclization-decarboxylative-protonation reaction triggered by an unprecedented benzhydryl-derived cupreine organocatalyst. This cyclization sequence was extended to an emerging organocatalytic decarboxylative-chlorination reaction in the presence of trichloroquinolinone and by means of a bifunctional cinchona derived Br?nsted base which gave rise to the formation of dihydrocoumarins (up to 79:21 er) with a tertiary chlorinated stereocenter. (Figure presented.).
A palladium-catalyzed regioselective hydroesterification of alkenylphenols to lactones with phenyl formate as CO source
Wang, Haining,Dong, Ben,Wang, Yang,Li, Jingfu,Shi, Yian
supporting information, p. 186 - 189 (2014/01/23)
An effective Pd(OAc)2-PPh3 catalyzed hydroesterification of alkenylphenols with phenyl formate as CO surrogate is described. A variety of lactones are obtained in generally high yields with high regioselectivities. In one case, 76% ee is obtained with a chiral ligand.
