860000-78-8 Usage
Description
Methyl 2-benzyloxy-5-bromo-benzoate is a benzoic acid derivative featuring a methyl ester group and a benzyl ether group attached to the benzoate ring, with a bromine atom at the 5-position. This versatile compound is widely used in organic synthesis for creating pharmaceuticals, agrochemicals, and specialty chemicals.
Uses
Used in Organic Synthesis:
Methyl 2-benzyloxy-5-bromo-benzoate serves as a building block in organic synthesis, utilized for the production of various pharmaceuticals, agrochemicals, and specialty chemicals. Its ability to undergo esterification and nucleophilic substitution reactions makes it a valuable component in the synthesis of complex molecules.
Used in Pharmaceutical Development:
In the pharmaceutical industry, methyl 2-benzyloxy-5-bromo-benzoate is used as a key intermediate for the synthesis of new drug candidates. Its unique structure allows for selective cleavage of the benzyl ether group under specific conditions, enabling further manipulation and optimization of the molecule for targeted therapeutic applications.
Used in Agrochemical Production:
Methyl 2-benzyloxy-5-bromo-benzoate also plays a role in the agrochemical sector, where it is employed as a starting material for the development of new pesticides and other agricultural chemicals. Its versatility in chemical reactions facilitates the creation of effective and environmentally friendly products.
Overall, methyl 2-benzyloxy-5-bromo-benzoate is a crucial compound in the development of innovative chemical entities across multiple industries, thanks to its unique structure and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 860000-78-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,0,0,0 and 0 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 860000-78:
(8*8)+(7*6)+(6*0)+(5*0)+(4*0)+(3*0)+(2*7)+(1*8)=128
128 % 10 = 8
So 860000-78-8 is a valid CAS Registry Number.
860000-78-8Relevant articles and documents
Metal-free Synthesis of Spiro-2,2′-benzo[b]furan-3,3′-ones via PhI(OAc)2-Mediated Cascade Spirocyclization
Xing, Qingyu,Liang, Huiyuan,Bao, Mingmai,Li, Xuemin,Zhang, Jingran,Bi, Tianhao,Zhang, Yilin,Xu, Jun,Du, Yunfei,Zhao, Kang
supporting information, p. 4669 - 4673 (2019/09/17)
Treating the benzyl protected 3-hydroxy-1,3-bis(2-hydroxyphenyl)prop-2-en-1-ones solely with PhI(OAc)2 (PIDA) in DCE at room temperature readily furnished the seldom studied spiro-2,2′-benzo[b]furan-3,3′-ones in satisfactory to excellent yields. The hypervalent iodine reagent enables the metal-free cascade spirocyclization resulting in the dual oxidative C?O bond formation. (Figure presented.).
Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of
Xia, Zebin,Correa, Ricardo G.,Das, Jayanta K.,Farhana, Lulu,Castro, David J.,Yu, Jinghua,Oshima, Robert G.,Fontana, Joseph A.,Reed, John C.,Dawson, Marcia I.
experimental part, p. 233 - 249 (2012/03/10)
The parent phenol of adapalene and its (E)-cinnamic acid analogue were found to induce cancer cell apoptosis but cause adverse systemic effects when administered to mice. In contrast, their respective 5-Cl- and 3-Cl-substituted analogues had their adverse