860013-16-7Relevant articles and documents
Epimerization-Free C-Term Activation of Peptide Fragments by Ball Milling
Yeboue, Yves,Jean, Marion,Subra, Gilles,Martinez, Jean,Lamaty, Frédéric,Métro, Thomas-Xavier
, p. 631 - 635 (2021)
Peptides were produced in high yields and, if any, very low epimerization, by mechanochemical coupling of peptide fragments containing highly epimerization-prone and/or highly hindered amino acids at C-term. Ball milling was clearly identified as the key element enabling one to obtain such results.
Design of β-secretase inhibitors by introduction of a mandelyl moiety in DAPT analogues
Pietrancosta, Nicolas,Quelever, Gilles,Laras, Younes,Garino, Cedrik,Burlet, Stephane,Kraus, Jean Louis
, p. 585 - 594 (2007/10/03)
We report the synthesis of two series of compounds with 3,5-difluoromandelyl-alanyl or 3,5-difluorophenylacetylalany1 backbones coupled to various heterocyclic or peptidic moieties. These two series of compounds were evaluated for their inhibitory propert