86013-39-0Relevant articles and documents
Asymmetric Synthesis via Acetal Templates. 5. Reactions with Cyanotrimethylsilane. Enantioselective Preparation of Cyanohydrins and Derivatives
Elliott, John D.,Choi, Vanessa M. F.,Johnson, William S.
, p. 2294 - 2295 (2007/10/02)
The titanium tetrachloride catalyzed reaction of the 2(R),4-(R)pentanediol acetals 1a-c with cyanotrimethylsilane proceeds in excellent yield and high diastereoselectivity to give cyanohydrin ethers 3a-c, and conditions have been developed for conversion of these ethers into cyanohydrins, β-amino alcohols and α-hydroxy esters with optical purities of greater then 90 percent.