86028-91-3 Usage
General Description
Ethyl L-thiazolidine-4-carboxylate hydrochloride, also known as pioglitazone hydrochloride, is a pharmaceutical compound that belongs to the class of thiazolidinediones. It is commonly used as an oral medication for the treatment of type 2 diabetes mellitus. Pioglitazone hydrochloride works by improving the body's sensitivity to insulin, leading to better control of blood sugar levels. It primarily functions by activating peroxisome proliferator-activated receptor gamma (PPAR-γ) to regulate glucose and lipid metabolism. In addition to its antidiabetic properties, pioglitazone hydrochloride has been found to have potential benefits in reducing inflammation and improving cardiovascular health. However,
Check Digit Verification of cas no
The CAS Registry Mumber 86028-91-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,0,2 and 8 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 86028-91:
(7*8)+(6*6)+(5*0)+(4*2)+(3*8)+(2*9)+(1*1)=143
143 % 10 = 3
So 86028-91-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H11NO2S.ClH/c1-2-9-6(8)5-3-10-4-7-5;/h5,7H,2-4H2,1H3;1H
86028-91-3Relevant articles and documents
Synthesis of heterocyclic platelet activating factor analogues
Zeidler, Juergen,Zimmermann, Werner
, p. 73 - 81 (1994)
The synthesis of heterocyclic analogues of the platelet activating factor is described. The preparation starts with acylating rac-tetrahydro-1,3-thiazine-4-carboxylic acid ethyl ester, with palmitoyl chloride to form the amide linkage. Following ester reduction, the phosphocholine part is introduced via 2-chloro-2-oxo-1,3,2-dioxaphospholane and subsequent ring opening with trimethylamine under pressure. Furthermore, the related L-thiazolidine analogue is prepared using the same procedure. In addition the sulfinyl and sulfonyl derivatives of this compound are obtained by oxidation with 3-chloro-perbencoic acid. From one sulfinyl intermediate the diastereomeres are separated and their conformations are determinated by 13C-NMR spectroscopy.