860376-18-7

Basic information

• Product Name: 1-chloro-2-(3-methylbenzyl)benzene
• Synonyms: 1-chloro-2-(3-methylbenzyl)benzene
• CAS NO: 860376-18-7
• Molecular Weight: 216.71
• Mol File: 860376-18-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-chloro-2-(3-methylbenzyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-2-(3-methylbenzyl)benzene(860376-18-7)
• EPA Substance Registry System: 1-chloro-2-(3-methylbenzyl)benzene(860376-18-7)

Safety Data

• Hazardous Substances Data: 860376-18-7(Hazardous Substances Data)

Upstream product

• 98-51-1 4-tert-butyltoluene 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 17849-38-6 2-Chlorobenzyl alcohol 
• 16419-60-6 2-Methylphenylboronic acid 
• 22184-24-3 o-chlorobenzyl acetate 
• 108-88-3 toluene 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 1192263-63-0 C₁₅H₂₃ClO 
• 89-98-5 2-chloro-benzaldehyde 
• 28987-79-3 m-tolylmagnesium bromide 

Downstream Products

• 859791-11-0 2-(3-methylbenzyl)benzonitrile 

Relevant articles and documents

Synthetic method of diarylmethanes

The invention discloses a synthetic method of diarylmethanes. The method is characterized in that benzyl pseudohalide and aromatic boric acid are reacted in an organic solvent under alkaline condition. The method employs easily available raw materials, conversion is realized under effect of no transition metal catalysis, water-free and oxygen-free are not required, Lewis acid catalysis is not required, the method has wide substrate universality, and various substituted diarylmethanes can be synthesized by the method.

Superacid BF3-H2O promoted benzylation of arenes with benzyl alcohols and acetates initiated by trace water

A convenient procedure employing simple starting materials benzyl alcohols and acetates as the benzyl donors to assemble a series of diarylalkanes through benzylation of arenes using in situ prepared superacid BF3-H 2O as an efficient promoter has been developed. The beneficial role of water in the reaction has been clarified with combination of control experiments and 11B NMR analysis. This reaction is a self-promoted model, which is triggered by the trace of water and continuously promoted by self released by-product water (or carboxylic acid). A wide range of substrates are investigated and the moderate to excellent yields and the good regioselectivities for secondary benzyl alcohols as well as arenes bearing electron-withdrawing groups have been achieved. As a result, moisture in the reaction system has been utilized as an efficient initiator in all benzylation cases.

ARYLALKYLATION OF 4-tert-BUTYLTOLUENE WITH SUBSTITUTED BENZYL CHLORIDES

The reaction of 4-alkylbenzyl chlorides with 4-tert-butyltoluene in the presence of titanium tetrachloride and ferric chloride leads to the formation of 2-methyl-4'-alkyl-5-tert-butyldiphenylmethanes.The arylalkylation of 4-tert-butyltoluene with 2- and 4-chlorobenzyl chlorides, catalyzed by titanium tetrachloride, leads to the formation of mixtures of 2-methyl-5-tert-butyldiphenylmethane, 2-tert-butyl-5-methyldiphenylmethane, and isomeric methyldiphenylmethanes containing a chloride atom in the benzyl fragment.The products of the reaction catalyzed by ferric chloride do not contain 2-tert-butyl-5-methylchlorodiphenylmethanes.The reacti on of 4-nitrobenzyl chloride with 4-tert-butyltoluene in the presence of ferric chloride leads to the formation of a mixture of 2-methyl-4'-nitro-5-tert-butyldiphenylmethane and isomeric methylnitrodiphenylmethanes.Under the influence of AlCl3-CH3NO2 in benzene 2,4'-dimethyl-5-tert-butyldiphenylmethane eliminates both the 4-methylbenzyl group and the tert-butyl group.Under analogous conditions 2-methyl-5-tert-butyldiphenylmethanes containing a chlorine atom or a nitro group in the benzyl fragment are dealkylated with the elimination of only the tert-butyl group.