860779-35-7

Basic information

• Product Name: [(E)-(1S,2S)-1-((S)-3-Fluoro-pyrrolidine-1-carbonyl)-2-(4-pyridin-4-yl-phenyl)-pent-3-enyl]-carbamic acid tert-butyl ester
• CAS NO: 860779-35-7
• Molecular Weight: 453.557
• Mol File: 860779-35-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(E)-(1S,2S)-1-((S)-3-Fluoro-pyrrolidine-1-carbonyl)-2-(4-pyridin-4-yl-phenyl)-pent-3-enyl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(E)-(1S,2S)-1-((S)-3-Fluoro-pyrrolidine-1-carbonyl)-2-(4-pyridin-4-yl-phenyl)-pent-3-enyl]-carbamic acid tert-butyl ester(860779-35-7)
• EPA Substance Registry System: [(E)-(1S,2S)-1-((S)-3-Fluoro-pyrrolidine-1-carbonyl)-2-(4-pyridin-4-yl-phenyl)-pent-3-enyl]-carbamic acid tert-butyl ester(860779-35-7)

Safety Data

• Hazardous Substances Data: 860779-35-7(Hazardous Substances Data)

Upstream product

• 690258-03-8 (βS)-4-bromo-N-(tert-butoxycarbonyl)-β-[(1E)-prop-1-en-1-yl]-L-phenylalanine 
• 705292-97-3 (3S)-1-[(2S,3S,4E)-3-(4-bromophenyl)-2-(tert-butoxycarbonylamino)hex-4-enoyl]-3-fluoropyrrolidine 
• 1692-15-5 4-pyridylboronic acid 

Downstream Products

• 860779-43-7 [(1S,2S)-1-((S)-3-Fluoro-pyrrolidine-1-carbonyl)-3-oxo-2-(4-pyridin-4-yl-phenyl)-propyl]-carbamic acid tert-butyl ester 
• 860779-51-7 (2S,3S)-3-tert-Butoxycarbonylamino-4-((S)-3-fluoro-pyrrolidin-1-yl)-4-oxo-2-(4-pyridin-4-yl-phenyl)-butyric acid 

Relevant articles and documents

Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors

anti-Substituted biaryl β-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors that suffer from suboptimal selectivity and pharmacokinetics. This letter describes the substitution of the β-methyl substituent with β-polar subst