860814-98-8Relevant articles and documents
Synthesis of phenylacetic acid regioisomers possessing an N-substituted 1,2-dihydropyrid-2-one pharmacophore - Evaluation as inhibitors of cyclooxygenases and 5-lipoxygenase
Yu, Gang,Chowdhury, Morshed A.,Huang, Zhangjian,Abdellatif, Khaled R. A.,Knaus, Edward E.
experimental part, p. 617 - 622 (2011/11/13)
The Suzuki-Miyaura cross-coupling reaction provides a useful method for the synthesis of methyl 2-(2-chloropyridyl or 2-methoxypyridyl)phenylacetates. The 2-chloropyridyl or 2-methoxypyridyl ring system can be readily elaborated to N-substituted (OH, Me, CHF2, H) 1,2-dihydropyrid-2-one ring systems that are useful synthons for use in bioorganic and medicinal chemistry applications.