861064-70-2

Basic information

• Product Name: methyl 2-(3,4-dibromophenyl)acetate
• Synonyms: methyl 2-(3,4-dibromophenyl)acetate
• CAS NO: 861064-70-2
• Molecular Weight: 307.969
• Mol File: 861064-70-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 2-(3,4-dibromophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(3,4-dibromophenyl)acetate(861064-70-2)
• EPA Substance Registry System: methyl 2-(3,4-dibromophenyl)acetate(861064-70-2)

Safety Data

• Hazardous Substances Data: 861064-70-2(Hazardous Substances Data)

Upstream product

• 249647-27-6 3,4-dibromophenylacetonitrile 
• 64382-93-0 1,2-dibromo-4-(bromomethyl)benzene 
• 67-56-1 methanol 
• 619323-15-8 2-(3,4-dibromophenyl)acetic acid 

Downstream Products

• 619323-23-8 methyl 2-(3,4-dibromophenyl)pent-4-enoate 

Relevant articles and documents

Functionalization of Piperidine Derivatives for the Site-Selective and Stereoselective Synthesis of Positional Analogues of Methylphenidate

Rhodium-catalyzed C?H insertions and cyclopropanations of donor/acceptor carbenes have been used for the synthesis of positional analogues of methylphenidate. The site selectivity is controlled by the catalyst and the amine protecting group. C?H functionalization of N-Boc-piperidine using Rh2(R-TCPTAD)4, or N-brosyl-piperidine using Rh2(R-TPPTTL)4 generated 2-substitited analogues. In contrast, when N-α-oxoarylacetyl-piperidines were used in combination with Rh2(S-2-Cl-5-BrTPCP)4, the C?H functionalization produced 4-susbstiuted analogues. Finally, the 3-substituted analogues were prepared indirectly by cyclopropanation of N-Boc-tetrahydropyridine followed by reductive regio- and stereoselective ring-opening of the cyclopropanes.