86137-72-6Relevant articles and documents
Synthesis and evaluation of pyrrole polyamide-2′-deoxyguanosine 5′-phosphate hybrid
Kawashima, Etsuko,Nakanishi, Yasuhiro,Terui, Yusuke,Tomitori, Hideyuki,Kashiwagi, Keiko,Ohba, Yusuke,Kamaike, Kazuo
, p. 196 - 205 (2013/06/04)
Pyrrole polyamide-2′-deoxyguanosine 5′-phosphate hybrid (Hybrid 4) was synthesized and evaluated in terms of the inhibition of mouse mammary carcinoma FM3A cell growth. Hybrid 4 was found to exhibit dose-dependent inhibition of cell growth.
Nucleotides: Part LXI: Phthaloyl strategy: A new concept of oligonucleotide synthesis
Beier, Markus,Pfleiderer, Wolfgang
, p. 633 - 644 (2007/10/03)
A new alternative strategy of oligonucleotide synthesis was developed by use of the phthaloyl protecting group for the exocyclic amino functions of the nucleobases (see 9-12). This approach combines the advantages of cheap and easily accessible monomeric building blocks (see 17- 20), standard machine-aided oligonucleotide synthesis, and a fast deprotection protocol which is orthogonal to the cleavage procedure from the solid support. The crude oligonucleotides show high purity and require, in general, no further chromatographic purification.
Synthesis of Oligonucleotide Adducts of the Bay Region Diol Epoxide Metabolites of Carcinogenic Polycyclic Aromatic Hydrocarbons
Lee, Hongmee,Luna, Ernestina,Hinz, Michael,Stezowski, John J.,Kiselyov, Alexander S.,Harvey, Ronald G.
, p. 5604 - 5613 (2007/10/03)
An efficient method for the site-specific synthesis of adducts between the biologically active diol epoxide metabolites of carcinogenic polycyclic aromatic hydrocarbons (PAHs) and oligonucleotides in which a PAH component of predetermined stereochemistry